2. PROTAC
  3. PROTAC Linkers
  4. Propynyl-PEG1-Ac

Propynyl-PEG1-Ac is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propynyl-PEG1-Ac is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Propynyl-PEG1-Ac Chemical Structure

Propynyl-PEG1-Ac Chemical Structure

CAS No. : 944561-45-9

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Based on 1 publication(s) in Google Scholar

Propynyl-PEG1-Ac Related Antibodies

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Description

Propynyl-PEG1-Ac is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propynyl-PEG1-Ac is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Propynyl-PEG1-Ac Related Antibodies
Molecular Weight

158.15

Formula

C7H10O4
CAS No.
Appearance

Liquid (Density: 1.169±0.06 g/cm3)

Color

Colorless to light yellow

SMILES

O=C(O)COCCOCC#C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Propynyl-PEG1-Ac Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Propynyl-PEG1-Ac944561-45-9PROTAC LinkersInhibitorinhibitorinhibit

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