Prostaglandin A3  (Synonyms: PGA3)

Prostaglandin A3 is a non-enzymatic dehydration product of prostaglandin E3 (PGE3). Prostaglandin A3 showed good affinity for canine EP2 and EP4 receptors with IC₅₀ values of 120 and 20 nM, respectively. The K_i value of Prostaglandin A3 for human PPARγ was 188 μM^[1][2][3].

332.43

C₂₀H₂₈O₄

36614-31-0

O=C1[C@@H]([C@H](C=C1)/C=C/[C@H](C/C=C\CC)O)C/C=C\CCCC(O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Hibbs TA, et al. Molecular cloning and characterization of the canine prostaglandin E receptor EP2 subtype. Prostaglandins Other Lipid Mediat. 1999 May;57(2-3):133-47.  [Content Brief]

  [2]. Castleberry TA, et al. Molecular cloning and functional characterization of the canine prostaglandin E2 receptor EP4 subtype. Prostaglandins Other Lipid Mediat. 2001 Jul;65(4):167-87.  [Content Brief]

  [3]. Ferry G, et al. Binding of prostaglandins to human PPARgamma: tool assessment and new natural ligands. Eur J Pharmacol. 2001 Apr 6;417(1-2):77-89.  [Content Brief]