2. PROTAC Protein Tyrosine Kinase/RTK
  3. PROTACs c-Met/HGFR
  4. PROTAC c-Met degrader-1

PROTAC c-Met degrader-1 (Compound Met-DD4) is an orally active PROTAC degrader for c-Met with a DC50 of 6.21 nM. PROTAC c-Met degrader-1 inhibits the proliferation of c-Met-addicted cell MKN-45 with an IC50 of 4.37 nM, and arrests the cell cycle at G0/G1 phase. PROTAC c-Met degrader-1 exhibits antitumor efficacy in MKN-45 xenograft mouse models. (Pink: Ligand for target protein (HY-13404); Blue: Ligand for E3 ligase (HY-W087383); Black: Linker (HY-W074901))

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PROTAC c-Met degrader-1 Chemical Structure

PROTAC c-Met degrader-1 Chemical Structure

CAS No. : 3056647-52-7

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PROTAC c-Met degrader-1 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

PROTAC c-Met degrader-1 (Compound Met-DD4) is an orally active PROTAC degrader for c-Met with a DC50 of 6.21 nM. PROTAC c-Met degrader-1 inhibits the proliferation of c-Met-addicted cell MKN-45 with an IC50 of 4.37 nM, and arrests the cell cycle at G0/G1 phase. PROTAC c-Met degrader-1 exhibits antitumor efficacy in MKN-45 xenograft mouse models[1]. (Pink: Ligand for target protein (HY-13404); Blue: Ligand for E3 ligase (HY-W087383); Black: Linker (HY-W074901))

IC50 & Target

c-Met

6.21 nM (DC50)

Molecular Weight

820.87

Formula

C45H41FN10O5
CAS No.
SMILES

FC1=C(C=CC(C(C=N2)=NN3C2=NC=C3CC4=CC5=C(C=C4)N=CC=C5)=C1)C(N6CCC(CN7CCN(C8=CC9=C(C=C8)C(N(C9=O)C(C(N%10)=O)CCC%10=O)=O)CC7)CC6)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC c-Met degrader-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC c-Met degrader-13056647-52-7PROTACsc-Met/HGFRorally activeBALB/c nude mouseMKN-45Inhibitorinhibitorinhibit

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