2. PROTAC Others
  3. Others PROTACs
  4. PROTAC Cbl-b-IN-1

PROTAC Cbl-b-IN-1 is a PROTAC targeting Cbl-b. PROTAC Cbl-b-IN-1 consists of PROTAC target protein ligand Cbl-b-IN-21 (HY-159615), PROTAC Linker Cbz-Pip-2C-Pip-C-Pip (HY-159617) and E3 ubiquitin ligase ligand (3S)Lenalidomide-5-Br (HY-W797329), of which the conjugate of E3 ubiquitin ligase ligand + Linker is (3S)Lenalidomide-5-Pip-C-Pip-2C-Pip (HY-159618).

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PROTAC Cbl-b-IN-1 Chemical Structure

PROTAC Cbl-b-IN-1 Chemical Structure

CAS No. : 3035210-39-7

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PROTAC Cbl-b-IN-1 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

PROTAC Cbl-b-IN-1 is a PROTAC targeting Cbl-b. PROTAC Cbl-b-IN-1 consists of PROTAC target protein ligand Cbl-b-IN-21 (HY-159615), PROTAC Linker Cbz-Pip-2C-Pip-C-Pip (HY-159617) and E3 ubiquitin ligase ligand (3S)Lenalidomide-5-Br (HY-W797329), of which the conjugate of E3 ubiquitin ligase ligand + Linker is (3S)Lenalidomide-5-Pip-C-Pip-2C-Pip (HY-159618)[1].

IC50 & Target

Cbl-b[1]
Molecular Weight

1023.16

Formula

C53H65F3N12O6
CAS No.
SMILES

OC=O.FC(F)(C1=CC(CN2CCN(CC2)CCN3CCC(CC3)CN4CCN(C5=CC=C(C(N([C@@H]6C(NC(CC6)=O)=O)C7)=O)C7=C5)CC4)=CN8C1=CN(C9=CC([C@H](C%10=NN=CN%10C)C%11CCC%11)=CC=C9)C8=O)F
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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PROTAC Cbl-b-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC Cbl-b-IN-13035210-39-7OthersPROTACsInhibitorinhibitorinhibit

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