2. PROTAC Vitamin D Related/Nuclear Receptor
  3. PROTACs Estrogen Receptor/ERR
  4. PROTAC ERα Degrader-7

PROTAC ERα Degrader-7 (compound i-320) is a potent estrogen receptor alpha(ERα) PROTAC degrader with a DC50 value of 0.000006 µM. PROTAC ERα Degrader-7 comprises a cereblon-binding moiety LBM linked to a ligand ERBM that binds ERα and comprises a benzofused partially saturated 6-membered carbocyclic or heterocyclic ring.

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PROTAC ERα Degrader-7 Chemical Structure

PROTAC ERα Degrader-7 Chemical Structure

CAS No. : 3025781-93-2

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PROTAC ERα Degrader-7 Related Antibodies

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

View All Estrogen Receptor/ERR Isoform Specific Products:

View All Isoforms
Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

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Description

PROTAC ERα Degrader-7 (compound i-320) is a potent estrogen receptor alpha(ERα) PROTAC degrader with a DC50 value of 0.000006 µM. PROTAC ERα Degrader-7 comprises a cereblon-binding moiety LBM linked to a ligand ERBM that binds ERα and comprises a benzofused partially saturated 6-membered carbocyclic or heterocyclic ring[1].

IC50 & Target[1]

ERα

0.000006 μM (DC50)

Molecular Weight

773.91

Formula

C46H49F2N5O4
CAS No.
SMILES

FC1(C[C@H](C2=CC=C(C=C2)C)[C@H](C3=CC=C(N4CCC(CC4)CN5CCN(C6=CC=C(C(N([C@@H]7C(NC(CC7)=O)=O)C8)=O)C8=C6)CC5)C=C3)C9=CC=C(O)C=C91)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC ERα Degrader-7 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC ERα Degrader-73025781-93-2PROTAC ERα Degrader7PROTAC ERα Degrader 7PROTACsEstrogen Receptor/ERRInhibitorinhibitorinhibit

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