PROTAC PTP1B degrader 1

Cat. No.: HY-158381: FAQs
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PROTAC PTP1B degrader 1 (compound 75) is a CRBN-based PTP1B PROTAC degrader, with DC₅₀ values of 0.2 μM (48 h) and 0.05 μM (72 h) (Red: PTP1B ligand Oleanolic acid (HY-N0156); Black: linker; Blue: CRBN ligand).

For research use only. We do not sell to patients.

PROTAC PTP1B degrader 1 Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 1000	Get quote 6 - 8 weeks 6 - 8 weeks 5 - 7 weeks	Estimated Time of Arrival: December 31
5 mg	USD 2500	Get quote 6 - 8 weeks 6 - 8 weeks 5 - 7 weeks	Estimated Time of Arrival: December 31
10 mg	USD 3800	Get quote 6 - 8 weeks 6 - 8 weeks 5 - 7 weeks	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
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Customer Review

Description	PROTAC PTP1B degrader 1 (compound 75) is a CRBN-based PTP1B PROTAC degrader, with DC₅₀ values of 0.2 μM (48 h) and 0.05 μM (72 h) (Red: PTP1B ligand Oleanolic acid (HY-N0156); Black: linker; Blue: CRBN ligand)^[1].
In Vivo	PROTAC PTP1B degrader 1 (compound 75) reduces blood glucose AUC_0–2h to 29% in an oral glucose tolerance test and activated the IRS-1/PI3K/Akt signaling pathway in HepG2 cells, showing promise for long-term antidiabetic therapy^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	1057.40
Formula	C₆₁H₉₂N₄O₁₁
SMILES	O=C(N1C2C(NC(CC2)=O)=O)C3=CC=CC(NC(CCCCCOCCOCCOCCOCCCCCCNC([C@]45[C@](CC(C)(CC5)C)([H])C6=CC[C@@]([C@@]7([C@@](C(C)([C@H](CC7)O)C)([H])CC8)C)([H])[C@]8(C)[C@@]6(CC4)C)=O)=O)=C3C1=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (263 KB) Handling Instructions (2659 KB)
References	[1]. Zunhua Yang, et al. Discovery of Selective Proteolysis-Targeting Chimera Degraders Targeting PTP1B as Long-Term Hypoglycemic Agents. J Med Chem. 2024 May 9;67(9):7569-7584. [Content Brief]