2. Epigenetics PROTAC
  3. Epigenetic Reader Domain PROTACs
  4. PROTAC SMARCA2/4-degrader-34

PROTAC SMARCA2/4-degrader-34 (compound 38) is a potent is a potent SMARCA2 and SMARCA4 PROTAC degrader. PROTAC SMARCA2/4-degrader-34 shows PXR binding affinity with DC50 value of 85.1 nM. PROTAC SMARCA2/4-degrader-34 decreases the protein expression of 3xFLAG-PXR. (Pink: Ligand for target protein (HY-169280); Black: Linker (HY-43048); Blue: Ligand for E3 ligase (HY-125845).

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PROTAC SMARCA2/4-degrader-34 Chemical Structure

PROTAC SMARCA2/4-degrader-34 Chemical Structure

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PROTAC SMARCA2/4-degrader-34 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

PROTAC SMARCA2/4-degrader-34 (compound 38) is a potent is a potent SMARCA2 and SMARCA4 PROTAC degrader. PROTAC SMARCA2/4-degrader-34 shows PXR binding affinity with DC50 value of 85.1 nM. PROTAC SMARCA2/4-degrader-34 decreases the protein expression of 3xFLAG-PXR. (Pink: Ligand for target protein (HY-169280); Black: Linker (HY-43048); Blue: Ligand for E3 ligase (HY-125845)[1].

Molecular Weight

1127.35

Formula

C58H78N8O13S
SMILES

O=C(C1=CC=C(C(NC(C2=C(N(N=N2)C3=CC(OC)=C(C=C3OC)OCCCCCCOCCOCC(N[C@H](C(N4[C@@H](C[C@H](C4)O)C(NCC5=CC=C(C=C5)C6=C(N=CS6)C)=O)=O)C(C)(C)C)=O)C)=O)=C1)O[C@@H](CC)CCC)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC SMARCA2/4-degrader-34 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC SMARCA2/4-degrader-34Epigenetic Reader DomainPROTACsSNU-C4 3xFLAG-PXR KI cellsSNU-C4 cells3xFLAG-PXRcytotoxicInhibitorinhibitorinhibit

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HY-169279
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