2. PROTAC Epigenetics
  3. PROTACs Epigenetic Reader Domain
  4. PROTAC SMARCA2 degrader-31

PROTAC SMARCA2-degrader-36 (compound 38) is a SMARCA2 degrader and can reach the the degradation rate of 99 % at the 100 nM in H929 cells. PROTAC SMARCA2-degrader-36 shows anti-proliferative activity and can be used for study of cancer(Structure Note: PINK SMARCA2 ligand HY-44012; Blue, VHL ligand (HY-112078); Black, linker HY-W014125).

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PROTAC SMARCA2 degrader-31 Chemical Structure

PROTAC SMARCA2 degrader-31 Chemical Structure

CAS No. : 2380274-45-1

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PROTAC SMARCA2 degrader-31 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

PROTAC SMARCA2-degrader-36 (compound 38) is a SMARCA2 degrader and can reach the the degradation rate of 99 % at the 100 nM in H929 cells. PROTAC SMARCA2-degrader-36 shows anti-proliferative activity and can be used for study of cancer(Structure Note: PINK SMARCA2 ligand HY-44012; Blue, VHL ligand (HY-112078); Black, linker HY-W014125)[1].

Molecular Weight

896.15

Formula

C48H65N9O6S
CAS No.
SMILES

OC1=C(C2=CC(N3CCN(C(CCCCCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C)=O)C[C@@H](O)C4)=O)=O)=O)CC3)=C(N)N=N2)C=CC=C1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC SMARCA2 degrader-31 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC SMARCA2 degrader-312380274-45-1PROTACsEpigenetic Reader DomainH929 cellsanti-proliferativeInhibitorinhibitorinhibit

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