2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Chemokine & Receptors
  5. CXC Chemokines
  6. CTAP-III/CXCL7

CTAP-III/CXCL7

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CXCL7 is a platelet-derived growth factor that belongs to the ELR+ CXC chemokine family, functioning as a potent chemoattractant and activator of neutrophils through binding to its receptor CXCR2[1].
CXCL7, a member of the CXC chemokine subfamily, is translated as a proprotein and cleaved into several smaller forms, each with particular functions. In humans, the CXCL7 gene is translated as a 14 kDa proprotein, designated leucocytederived growth factor (LDGF), which is cleaved into several smaller forms, platelet basic protein (PBP), connective tissue activating protein III (CTAP-III) and β-thrombogulin (β-TG), and NAP-2. The longest form, PBP or LDGF, is expressed in platelets and megakaryocytes and is reported to be a fibroblast mitogen. CTAP-III is a 85 amino acid protein and can be converted to 70 amino acid NAP-2 by enzymatic removal of 15 residues. CTAP-III is suggested to support megakaryocyte maturation and platelet production and is involved in resistance to mycobacteria by augmenting reactive oxygen production. NAP-2, the smallest protein in this series, is a neutrophil-activating mediator, stimulating functions such as lysosomal enzyme degranulation, but is reported to inhibit megakaryocytopoiesis[2].
CXCL7 has been demonstrated to participate in a variety of cellular processes, such as DNA synthesis, glycolysis, mitosis, intracellular cAMP accumulation, prostaglandin E2 secretion, as well as the synthesis of hyaluronic acid and plasminogen activator. Moreover, it is also an antimicrobial protein with bactericidal and antifungal activity. Recently, CXCL7 has been found to be deregulated in human cancers, and plays a role in tumor growth. For instance, CXCL7 is found to promote the growth of clear cell renal cell carcinoma. The CXCL7/CXCR2 signaling plays a promoting role in several common malignancies, including lung, renal, colon, and breast cancer[1].

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Cat. No. Product Name / Synonyms Species Source
  • HY-P7267
    NAP-2/CXCL7 Protein, Human (CHO)

    rHuNAP-2/CXCL7; C-X-C motif chemokine 7; Platelet basic protein; MDGF; SCYB7

    		Human CHO
    CXCL7 (also known as neutrophil activating peptide 2, NAP-2) is a platelet-derived growth factor that belongs to the ELR+ CXC chemokine family, functioning as a potent chemoattractant and activator of neutrophils through binding to its receptor CXCR2. NAP-2/CXCL7 Protein, Human (CHO) is produced in CHO cells, and consists of 70 amino acids (A59-D128) .
  • HY-P7268
    NAP-2/CXCL7 Protein, Human

    rHuNAP-2/CXCL7; C-X-C motif chemokine 7; Platelet basic protein; MDGF; SCYB7

    		Human E. coli
    CXCL7 (also known as neutrophil activating peptide 2, NAP-2) is a platelet-derived growth factor that belongs to the ELR+ CXC chemokine family, functioning as a potent chemoattractant and activator of neutrophils through binding to its receptor CXCR2. NAP-2/CXCL7 Protein, Human is produced in E. coli , and consists of 70 amino acids (A59-D128).
  • HY-P72676
    NAP-2/CXCL7 Protein, Human (HEK293, His)

    C-X-C motif chemokine 7; PBP; LDGF; MDGF; CTAP-III; PPBP; NAP-2; CXCL7

    		Human HEK293
    CXCL7 (also known as neutrophil activating peptide 2, NAP-2) is a platelet-derived growth factor that belongs to the ELR+ CXC chemokine family, functioning as a potent chemoattractant and activator of neutrophils through binding to its receptor CXCR2. NAP-2/CXCL7 Protein, Human (HEK 293, His) is produced in HEK293 cells with six C-Terminal His-tags. It consists of 94 amino acids (S35-D128).
  • HY-P700049AF
    Animal-Free NAP-2/CXCL7 Protein, Human (His)

    NAP-2/CXCL7; C-X-C motif chemokine 7; Platelet basic protein; MDGF; SCYB7

    		Human E. coli
    NAP-2/CXCL7 protein (LA-PF4) triggers DNA synthesis, mitosis, glycolysis, cAMP accumulation, and hyaluronic acid synthesis. It contributes to the formation of plasminogen activator in human synovial cells and acts as a CXCR1/CXCR2 ligand together with variants such as NAP-2 (73). Animal-Free NAP-2/CXCL7 Protein, Human (His) is the recombinant human-derived animal-FreeNAP-2/CXCL7 protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free NAP-2/CXCL7 Protein, Human (His) is 70 a.a., with molecular weight of ~8.43 kDa.
  • HY-P7269
    NAP-2/CXCL7 Protein, Rat

    rRtNAP-2/CXCL7; C-X-C motif chemokine 7; Platelet basic protein; MDGF; SCYB7

    		Rat E. coli
    CXCL7 (also known as neutrophil activating peptide 2, NAP-2) is a platelet-derived growth factor that belongs to the ELR+ CXC chemokine family, functioning as a potent chemoattractant and activator of neutrophils through binding to its receptor CXCR2. NAP-2/CXCL7 Protein, Rat is produced in E. coli , and consists of 62 amino acids (I46-I107).
  • HY-P7301
    NAP-2/CXCL7 Protein, Rat (CHO)

    rRtThymusChemokine-1/CXCL7; Ppbp; Rtck1

    		Rat CHO
    CXCL7 (also known as neutrophil activating peptide 2, NAP-2) is a platelet-derived growth factor that belongs to the ELR+ CXC chemokine family, functioning as a potent chemoattractant and activator of neutrophils through binding to its receptor CXCR2. NAP-2/CXCL7 Protein, Rat (CHO) is produced in CHO cells, and consists of 62 amino acids (I46-I107).
  • HY-P76854
    CXCL7 Protein, Cynomolgus (HEK293, Fc)

    C-X-C motif chemokine 7; PBP; LDGF; MDGF; CTAP-III; PPBP; NAP-2; CXCL7

    		Cynomolgus HEK293
    CXCL7 (also known as neutrophil activating peptide 2, NAP-2) is a platelet-derived growth factor that belongs to the ELR+ CXC chemokine family, functioning as a potent chemoattractant and activator of neutrophils through binding to its receptor CXCR2. CXCL7 Protein, Cynomolgus (HEK293, Fc) is produced in HEK293 cells with a N-Terminal Fc-tag. It consists of 70 amino acids (T59-D128).
  • HY-P700174AF
    Animal-Free NAP-2/CXCL7 Protein, Mouse (His)

    C-X-C motif chemokine 7; PBP; LDGF; MDGF; CTAP-III; PPBP; NAP-2; CXCL7

    		Mouse E. coli
    NAP-2/CXCL7 proteins are members of the intercrine alpha family and are associated with chemokines that regulate intercellular communication and immune responses. As part of this family, NAP-2/CXCL7 may regulate inflammatory processes and cellular interactions. Animal-Free NAP-2/CXCL7 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeNAP-2/CXCL7 protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free NAP-2/CXCL7 Protein, Mouse (His) is 74 a.a., with molecular weight of ~8.93 kDa.
  • HY-P700175AF
    Animal-Free NAP-2/CXCL7 Protein, Mouse (62a.a, His)

    C-X-C motif chemokine 7; PBP; LDGF; MDGF; CTAP-III; PPBP; NAP-2; CXCL7

    		Mouse E. coli
    NAP-2/CXCL7 proteins are members of the intercrine alpha family and are associated with chemokines that regulate intercellular communication and immune responses. As part of this family, NAP-2/CXCL7 may regulate inflammatory processes and cellular interactions. Animal-Free NAP-2/CXCL7 Protein, Mouse (62a.a, His) is the recombinant mouse-derived animal-FreeNAP-2/CXCL7 protein, expressed by E. coli , with N-His labeled tag.
  • HY-P75698
    NAP-2/CXCL7 Protein, Mouse (His)

    C-X-C motif chemokine 7; PBP; LDGF; MDGF; CTAP-III; PPBP; NAP-2; CXCL7

    		Mouse E. coli
    CXCL7 (also known as neutrophil activating peptide 2, NAP-2) is a platelet-derived growth factor that belongs to the ELR+ CXC chemokine family, functioning as a potent chemoattractant and activator of neutrophils through binding to its receptor CXCR2. NAP-2/CXCL7 Protein, Mouse (His) is produced in E.coil with a N-Terminal His-tag. It consists of 74 amino acids (K40-Y113).
  • HY-P75699
    NAP-2/CXCL7 Protein, Rat (HEK293, Fc)

    C-X-C motif chemokine 7; PBP; LDGF; MDGF; CTAP-III; PPBP; NAP-2; CXCL7

    		Rat HEK293
    CXCL7 (also known as neutrophil activating peptide 2, NAP-2) is a platelet-derived growth factor that belongs to the ELR+ CXC chemokine family, functioning as a potent chemoattractant and activator of neutrophils through binding to its receptor CXCR2. NAP-2/CXCL7 Protein, Rat (HEK293, Fc) is produced in HEK293 cells with a N-Terminal Fc-tag. It consists of 62 amino acids (I46-I107).
  • HY-P75700
    NAP-2/CXCL7 Protein, Rat (P.pastoris, His)

    C-X-C motif chemokine 7; PBP; LDGF; MDGF; CTAP-III; PPBP; NAP-2; CXCL7

    		Rat P. pastoris
    CXCL7 (also known as neutrophil activating peptide 2, NAP-2) is a platelet-derived growth factor that belongs to the ELR+ CXC chemokine family, functioning as a potent chemoattractant and activator of neutrophils through binding to its receptor CXCR2. NAP-2/CXCL7 Protein, Rat (P.pastoris, His) is produced in P.pastoris with a C-Terminal His-tag. It consists of 74 amino acids (K38-Y111).
  • HY-P76855
    CXCL7 Protein, Cynomolgus/Rhesus Macaque (P.pastoris, His)

    C-X-C motif chemokine 7; PBP; LDGF; MDGF; CTAP-III; PPBP; NAP-2; CXCL7

    		Rhesus Macaque P. pastoris
    CXCL7 (also known as neutrophil activating peptide 2, NAP-2) is a platelet-derived growth factor that belongs to the ELR+ CXC chemokine family, functioning as a potent chemoattractant and activator of neutrophils through binding to its receptor CXCR2. CXCL7 Protein, Cynomolgus/Rhesus Macaque (P.pastoris, His) is produced in P.pastoris with a C-Terminal His-tag. It consists of 94 amino acids (S35-D128).
Cat. No. Product Name Effect Purity