2. Recombinant Proteins
  3. Immune Checkpoint Proteins CD Antigens
  4. Inhibitory Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Dendritic Cell CD Proteins Epithelial cell CD Proteins
  5. LAIR-1/CD305

LAIR-1/CD305

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Leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1), also known as CD305, is a transmembrane glycoprotein inhibitory receptor characterized by an extracellular C2-type Ig-like domain and two ITIMs in the cytoplasmic tail. It is expressed not onl

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Cat. No. Product Name / Synonyms Species Source
  • HY-P70871
    LAIR1 Protein, Mouse (HEK293, His)

    Leukocyte-associated immunoglobulin-like receptor 1; LAIR-1; mLAIR-1; CD305; Lair1

    		Mouse HEK293
    The LAIR1 protein functions as an inhibitory receptor that negatively regulates NK cells, B cells, and T cells. LAIR1 is activated by tyrosine phosphorylation, recruits PTPN6 and PTPN11, and exerts downstream inhibitory effects. LAIR1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived LAIR1 protein, expressed by HEK293 , with C-6*His labeled tag.
  • HY-P78476
    LAIR1 Protein, Human (HEK293, His-Avi)

    CD305; HLAIR1; LAIR1; LAIR-1

    		Human HEK293
    LAIR1 protein has a negative regulatory effect on NK cells, B cells and T cells. It activates the phosphatases PTPN6 and PTPN11, inhibits calcium increases in B cells, and regulates cytokine production in CD4+ T cells. LAIR1 Protein, Human (HEK293, His-Avi) is the recombinant human-derived LAIR1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
  • HY-P72390
    LAIR1 Protein, Human (Biotinylated, HEK293, Avi-His)

    Leukocyte-Associated Immunoglobulin-Like Receptor 1; LAIR-1; hLAIR1; CD305; LAIR1

    		Human HEK293
    LAIR1 protein has a negative regulatory effect on NK cells, B cells and T cells. It activates the phosphatases PTPN6 and PTPN11, inhibits calcium increases in B cells, and regulates cytokine production in CD4+ T cells. LAIR1 Protein, Human (Biotinylated, HEK293, Avi-His) is the recombinant human-derived LAIR1 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag.
  • HY-P72529
    LAIR1 Protein, Human (HEK293, His)

    Leukocyte-Associated Immunoglobulin-Like Receptor 1; LAIR-1; hLAIR1; CD305

    		Human HEK293
    LAIR1 protein has a negative regulatory effect on NK cells, B cells and T cells. It activates the phosphatases PTPN6 and PTPN11, inhibits calcium increases in B cells, and regulates cytokine production in CD4+ T cells. LAIR1 Protein, Human (HEK293, His) is the recombinant human-derived LAIR1 protein, expressed by HEK293 , with C-6*His labeled tag.
  • HY-P74783
    LAIR1 Protein, Mouse (HEK293, Fc)

    Leukocyte-Associated Immunoglobulin-Like Receptor 1; LAIR-1; hLAIR1; CD305

    		Mouse HEK293
    The LAIR1 protein functions as an inhibitory receptor, negatively regulating NK cells, B-cells, and T-cells. Activated by tyrosine phosphorylation, LAIR1 recruits PTPN6 and PTPN11, exerting downstream inhibitory effects. It diminishes intracellular calcium increase triggered by B-cell receptor ligation and independently modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG while inducing TGF-beta secretion. LAIR1 also regulates IgG and IgE production, inhibits proliferation, induces apoptosis in myeloid leukemia cells, prevents NF-kappa-B p65 subunit translocation, and inhibits I-kappa-B alpha phosphorylation. LAIR1 associates with SH2 domains of PTPN6 and PTPN11 and binds with high affinity to extracellular matrix collagens, signifying a functionally significant interaction. LAIR1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived LAIR1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of LAIR1 Protein, Mouse (HEK293, Fc) is 112 a.a., with molecular weight of 49-53 kDa.
  • HY-P74784
    LAIR1 Protein, Human (144a.a, HEK293, hFc)

    Leukocyte-Associated Immunoglobulin-Like Receptor 1; LAIR-1; hLAIR1; CD305

    		Human HEK293
    LAIR1 protein has a negative regulatory effect on NK cells, B cells and T cells. It activates the phosphatases PTPN6 and PTPN11, inhibits calcium increases in B cells, and regulates cytokine production in CD4+ T cells. LAIR1 Protein, Human (144a.a, HEK293, hFc) is the recombinant human-derived LAIR1 protein, expressed by HEK293 , with C-hFc labeled tag.
  • HY-P74786
    LAIR1 Protein, Human (Biotinylated, 144a.a, HEK293, His)

    Leukocyte-Associated Immunoglobulin-Like Receptor 1; LAIR-1; hLAIR1; CD305

    		Human HEK293
    LAIR1 protein has a negative regulatory effect on NK cells, B cells and T cells. It activates the phosphatases PTPN6 and PTPN11, inhibits calcium increases in B cells, and regulates cytokine production in CD4+ T cells. LAIR1 Protein, Human (Biotinylated, 144a.a, HEK293, His) is the recombinant human-derived LAIR1 protein, expressed by HEK293 , with C-His labeled tag.
  • HY-P72528
    LAIR1 Protein, Rhesus Macaque (HEK293, His)

    Leukocyte-Associated Immunoglobulin-Like Receptor 1; LAIR-1; hLAIR1; CD305

    		Rhesus Macaque HEK293
    LAIR1 Protein is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. LAIR1 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived LAIR1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of LAIR1 Protein, Rhesus Macaque (HEK293, His) is 144 a.a., with molecular weight of 25-33 kDa.
Cat. No. Product Name Effect Purity