Protizinic acid 

Protizinic acid is an orally active non-steroidal antiinflammatory agent with antiinflammatory and antipyretic activity. Protizinic acid inhibits phospholipase A2 (PLA2) activity, and the IC₅₀ value is 210 μM^[1][2].

Protizinic acid not only inhibits the in vitro generation of leukokinin but also antagonizes to it on the receptor site of leukokinin^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In vivo leukokinin (LK) generation system using feline acute ischemia model, When 3 mg/kg Protizinic acid is injected twice intravenously to cats with acute cardiac ischemia, increased blood acid protease activity is inhibited and significant inhibitory action on the decrease of leukokininogen, the precursor of leukokinin, is observed^[1].
Oral administration of 30 mg/kg of Protizinic acid significantly inhibits arachidonic acid-induced erythema in guinea pigs^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

315.39

C₁₇H₁₇NO₃S

13799-03-6

CN1C2=C(C=CC(C(C)C(O)=O)=C2)SC3=CC(OC)=CC=C13

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. K Suzuki, et al. Effects of protizinic acid on leukokinin generation and its physiological action. Agents Actions. 1984 Jun;14(5-6):699-706.  [Content Brief]

  [2]. H Ohnishi, et al. Effects of protizinic acid on the prostaglandins system and the production of oxygen radicals. Nihon Yakurigaku Zasshi. 1982 Jun;79(6):561-9.  [Content Brief]