2. MAPK/ERK Pathway
  3. p38 MAPK
  4. PS-166276

PS-166276 is a highly potent and less cytotoxic inhibitor of p38. PS166276 has an IC50 of 28 nM at p38 kinase and 170 nM in the THP-1 TNFα assay.

For research use only. We do not sell to patients.

PS-166276 Chemical Structure

PS-166276 Chemical Structure

CAS No. : 348089-57-6

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PS-166276 Related Antibodies

Top Publications Citing Use of Products

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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Description

PS-166276 is a highly potent and less cytotoxic inhibitor of p38. PS166276 has an IC50 of 28 nM at p38 kinase and 170 nM in the THP-1 TNFα assay[1].

In Vivo

PS166276 (30 mg/kg, s.c., mice) inhibits LPS-induced TNFα production in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

398.51

Formula

C20H30N8O
CAS No.
SMILES

CC(C)CN(C)C1=NC(N[C@@H]2CCNC2)=NC(NC3=CC(C(N)=O)=CC=C3C)=N1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PS-166276 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PS-166276348089-57-6PS166276PS 166276p38 MAPKp38THP-1TNFαLPSInhibitorinhibitorinhibit

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