2. Immunology/Inflammation
  3. PSMA
  4. PSMA-IN-1

PSMA-IN-1 (compound 23) is an inhibitor of PSMA with a Ki value of 2.49 nM. PSMA-IN-1 inhibits tumor growth with high selectivity and specificity in PSMA+ xenograft models. PSMA-IN-1 is a NIR probe (λEX: 620 nm; λEM: 670 nm) used for tumor disappearance. PSMA-IN-1 can be used for research on prostate cancer.

For research use only. We do not sell to patients.

PSMA-IN-1 Chemical Structure

PSMA-IN-1 Chemical Structure

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PSMA-IN-1 Related Antibodies

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Description

PSMA-IN-1 (compound 23) is an inhibitor of PSMA with a Ki value of 2.49 nM. PSMA-IN-1 inhibits tumor growth with high selectivity and specificity in PSMA+ xenograft models. PSMA-IN-1 is a NIR probe (λEX: 620 nm; λEM: 670 nm) used for tumor disappearance. PSMA-IN-1 can be used for research on prostate cancer[1].

In Vivo

PSMA-IN-1 (0.33 mg/kg, i.v., one time) is a NIR probe (λEX: 620 nm; λEM: 670 nm) used for tumor disappearance, and acquires images at different time points after injection(2, 4, 8, 12, 24, and 48 h) [1].
PSMA-IN-1 (0.33 mg/kg, i.v., one time) inhibits tumor growth with high selectivity and specificity in the BALB/C nude mice tumor bearing model constructed with 22Rv1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 22Rv1 xenograft models in BALB/C nude mice[1]
Dosage: 0.33 mg/kg
Administration: Intravenous injection (i.v.), sacrificed at 55 h post-injection
Result: Increased TNR (tumor-to-normal tissue ratio) values from 3.20 at 2 h to 6.27 at 48 h.
Molecular Weight

1333.40

Formula

C66H80N10O20
SMILES

OC(C1=O)=C(NC[C@H](NC(N[C@@H](CCCCNC(CCCCC[N+]2=C(C(C)(C3=C2C=CC=C3)C)/C=C4C([O-])=C(C\4=O)/C=C5C(C)(C6=C(N/5CCCCCC(NCCCC[C@H](NC(N[C@H](C(O)=O)CNC(C7=O)=C(C7=O)O)=O)C(O)=O)=O)C=CC=C6)C)=O)C(O)=O)=O)C(O)=O)C1=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PSMA-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PSMA-IN-1PSMAProstate-specific membrane antigen22Rv1selectivexenograftprostate cancerInhibitorinhibitorinhibit

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