2. Immunology/Inflammation
  3. PSMA
  4. PSMA-IN-2

PSMA-IN-2 is an inhibitor of PSMA with a Ki value of 1.07 nM. PSMA-IN-2 displays favorable in vivo NIR imaging (λEM = 1088 nm, λex = 808 nm), and can be used for NIRII image-guided tumor resection surgery in PSMA-positive tumor-bearing mice.

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PSMA-IN-2 Chemical Structure

PSMA-IN-2 Chemical Structure

CAS No. : 2946600-14-0

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PSMA-IN-2 Related Antibodies

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Description

PSMA-IN-2 is an inhibitor of PSMA with a Ki value of 1.07 nM. PSMA-IN-2 displays favorable in vivo NIR imaging (λEM = 1088 nm, λex = 808 nm), and can be used for NIRII image-guided tumor resection surgery in PSMA-positive tumor-bearing mice[1].

IC50 & Target

PSMA

1.07 nM (Ki)

In Vivo

PSMA-IN-2 (compound 24) (0.85 mg/kg, i.v., 24 h)is confirmed by NIR-II imaging to bind specifically to PSMA in vivo[1].Animal assay : 22Rv1 xenograft models[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 22Rv1 xenograft models[1]
Dosage: 0.85 mg/kg
Administration: Intravenous injection (i.v.)
Result: Excreted from the blood pool, increasing signal intensity was observed in 22Rv1 xenograft over time as, the background signal became gradually weak, under 808 nm laser irradiation (1100 nm long-pass filter, 400 ms). Inhibition ranged from 38% to 52%, based on semi-quantitative data DCFPyL in tumors.
Molecular Weight

1257.27

Formula

C54H60N14O18S2
CAS No.
SMILES

CN(C1=CC=C(C2=C3N=S=NC3=C(C4=NSN=C42)C5=CC=C(C=C5)N(C)CCC(NCCCC[C@H](NC(N[C@H](C(O)=O)CNC(C6=O)=C(C6=O)O)=O)C(O)=O)=O)C=C1)CCC(NCCCC[C@H](NC(N[C@H](C(O)=O)CNC(C7=O)=C(C7=O)O)=O)C(O)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PSMA-IN-2 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PSMA-IN-22946600-14-0PSMAProstate-specific membrane antigen22Rv1selectivexenograftprostate cancerNIR imagingFluorescent DyeInhibitorinhibitorinhibit

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HY-149298
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