1. Immunology/Inflammation
  2. PSMA
  3. PSMA-IN-2

PSMA-IN-2 is an inhibitor of PSMA with a Ki value of 1.07 nM. PSMA-IN-2 displays favorable in vivo NIR imaging (λEM = 1088 nm, λex = 808 nm), and can be used for NIRII image-guided tumor resection surgery in PSMA-positive tumor-bearing mice.

For research use only. We do not sell to patients.

PSMA-IN-2 Chemical Structure

PSMA-IN-2 Chemical Structure

CAS No. : 2946600-14-0

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Description

PSMA-IN-2 is an inhibitor of PSMA with a Ki value of 1.07 nM. PSMA-IN-2 displays favorable in vivo NIR imaging (λEM = 1088 nm, λex = 808 nm), and can be used for NIRII image-guided tumor resection surgery in PSMA-positive tumor-bearing mice[1].

IC50 & Target

PSMA

1.07 nM (Ki)

In Vivo

PSMA-IN-2 (compound 24) (0.85 mg/kg, i.v., 24 h)is confirmed by NIR-II imaging to bind specifically to PSMA in vivo[1].Animal assay : 22Rv1 xenograft models[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 22Rv1 xenograft models[1]
Dosage: 0.85 mg/kg
Administration: Intravenous injection (i.v.)
Result: Excreted from the blood pool, increasing signal intensity was observed in 22Rv1 xenograft over time as, the background signal became gradually weak, under 808 nm laser irradiation (1100 nm long-pass filter, 400 ms). Inhibition ranged from 38% to 52%, based on semi-quantitative data DCFPyL in tumors.
Molecular Weight

1257.27

Formula

C54H60N14O18S2

CAS No.
SMILES

CN(C1=CC=C(C2=C3N=S=NC3=C(C4=NSN=C42)C5=CC=C(C=C5)N(C)CCC(NCCCC[C@H](NC(N[C@H](C(O)=O)CNC(C6=O)=C(C6=O)O)=O)C(O)=O)=O)C=C1)CCC(NCCCC[C@H](NC(N[C@H](C(O)=O)CNC(C7=O)=C(C7=O)O)=O)C(O)=O)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Product Name:
PSMA-IN-2
Cat. No.:
HY-149298
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