2. PI3K/Akt/mTOR
  3. mTOR
  4. PT-88

PT-88 is a highly selective inhibitor of mTOR (Mammalian target of rapamycin) (IC50=1.2 nM). PT-88 inhibits both mTORC1 and mTORC2 complexes, both of which are active forms of mTOR protein kinases and are closely associated with cell growth, proliferation, and survival. PT-88 can be used to study the role of mTOR in tumorigenesis and development, especially in the treatment of breast cancer.

For research use only. We do not sell to patients.

PT-88 Chemical Structure

PT-88 Chemical Structure

CAS No. : 2803307-04-0

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PT-88 Related Antibodies

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Description

PT-88 is a highly selective inhibitor of mTOR (Mammalian target of rapamycin) (IC50=1.2 nM). PT-88 inhibits both mTORC1 and mTORC2 complexes, both of which are active forms of mTOR protein kinases and are closely associated with cell growth, proliferation, and survival. PT-88 can be used to study the role of mTOR in tumorigenesis and development, especially in the treatment of breast cancer[1].

Molecular Weight

569.61

Formula

C30H31N7O5
CAS No.
SMILES

O=C(NC1=CC=C(C2=NC(N3C4COCC3CC4)=NC(N5[C@@H]6COC[C@H]5CC6)=N2)C=C1)NC7=CC8=C(C=C7)C(OC8)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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PT-88 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PT-882803307-04-0PT88PT 88mTORMammalian target of RapamycinCell proliferationAutophagyTumorigenesisComplexBreast cancerInhibitorinhibitorinhibit

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