2. Stem Cell/Wnt
  3. β-catenin
  4. PTK7/β-catenin-IN-2

PTK7/β-catenin-IN-2 (compound 04967) is an inhibitor of PTK7/β-catenin. It inhibits the binding of PTK7 to β-catenin (IC50: 5.6 μM), thereby inhibiting the signaling of the Wnt/β-catenin pathway. PTK7/β-catenin-IN-2 targets cell growth dependent on the Wnt signaling pathway and has anticancer properties. PTK7/β-catenin-IN-2 also showed inhibitory potency against p53 and MDM2 binding with an IC50 of 157.1 μM.

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PTK7/β-catenin-IN-2 Chemical Structure

PTK7/β-catenin-IN-2 Chemical Structure

CAS No. : 902434-29-1

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PTK7/β-catenin-IN-2 Related Antibodies

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Description

PTK7/β-catenin-IN-2 (compound 04967) is an inhibitor of PTK7/β-catenin. It inhibits the binding of PTK7 to β-catenin (IC50: 5.6 μM), thereby inhibiting the signaling of the Wnt/β-catenin pathway. PTK7/β-catenin-IN-2 targets cell growth dependent on the Wnt signaling pathway and has anticancer properties. PTK7/β-catenin-IN-2 also showed inhibitory potency against p53 and MDM2 binding with an IC50 of 157.1 μM[1].

IC50 & Target

IC50: 5.6 μM (Interaction between PTK7 and β-catenin)[1]; 157.1 μM (Interaction between p53 and MDM2)[1]
Molecular Weight

565.54

Formula

C30H34Cl2N6O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(CCC1=C(C)N2N=C(C3=CC=C(Cl)C=C3)C=C2N=C1C)NCCCN4CCN(CC4)C5=CC(Cl)=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMF : 25 mg/mL (44.21 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7682 mL 8.8411 mL 17.6822 mL
5 mM 0.3536 mL 1.7682 mL 3.5364 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF 1 mM 1.7682 mL 8.8411 mL 17.6822 mL 44.2055 mL
5 mM 0.3536 mL 1.7682 mL 3.5364 mL 8.8411 mL
10 mM 0.1768 mL 0.8841 mL 1.7682 mL 4.4206 mL
15 mM 0.1179 mL 0.5894 mL 1.1788 mL 2.9470 mL
20 mM 0.0884 mL 0.4421 mL 0.8841 mL 2.2103 mL
25 mM 0.0707 mL 0.3536 mL 0.7073 mL 1.7682 mL
30 mM 0.0589 mL 0.2947 mL 0.5894 mL 1.4735 mL
40 mM 0.0442 mL 0.2210 mL 0.4421 mL 1.1051 mL
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PTK7/β-catenin-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PTK7/β-catenin-IN-2902434-29-1β-cateninBeta cateninInhibitorinhibitorinhibit

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