2. Metabolic Enzyme/Protease
  3. Phosphatase Aldose Reductase
  4. PTP1B/AKR1B1-IN-2

PTP1B/AKR1B1-IN-2 (Compound 7f) is a dual PTP1B/AKR1B1 inhibitor (IC50s: 3.2 and 2.1 μM, Kis: 4.0 and 0.9μM). PTP1B/AKR1B1-IN-2 is an insulin-mimetic agent. PTP1B/AKR1B1-IN-2 improves glucose uptake in murine C2C12 myoblasts. PTP1B/AKR1B1-IN-2 can be used for research of Type 2 diabetes mellitus (T2DM).

For research use only. We do not sell to patients.

PTP1B/AKR1B1-IN-2 Chemical Structure

PTP1B/AKR1B1-IN-2 Chemical Structure

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PTP1B/AKR1B1-IN-2 Related Antibodies

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Description

PTP1B/AKR1B1-IN-2 (Compound 7f) is a dual PTP1B/AKR1B1 inhibitor (IC50s: 3.2 and 2.1 μM, Kis: 4.0 and 0.9μM). PTP1B/AKR1B1-IN-2 is an insulin-mimetic agent. PTP1B/AKR1B1-IN-2 improves glucose uptake in murine C2C12 myoblasts. PTP1B/AKR1B1-IN-2 can be used for research of Type 2 diabetes mellitus (T2DM)[1].

Molecular Weight

441.56

Formula

C23H23NO4S2
SMILES

O=C(CCN1C(/C(SC1=S)=C/C2=CC=CC(OCCCCC3=CC=CC=C3)=C2)=O)O
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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PTP1B/AKR1B1-IN-2 Related Classifications

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PTP1B/AKR1B1-IN-2PhosphataseAldose ReductaseGlucoseC2C12myoblastType 2 diabetes mellitusT2DMinsulinInhibitorinhibitorinhibit

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