Pyronaridine-d₄ tetraphosphate

Name: Pyronaridine-d 4 tetraphosphate
Brand: MedChemExpress
SKU: HY-14749AS
Rating: 4.5 (1 reviews)

Cat. No.: HY-14749AS Purity: 97.00%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Pyronaridine-d₄ (tetraphosphate) is the deuterium labeled Pyronaridine tetraphosphate[1]. Pyronaridine tetraphosphate is an orally active Mannich base anti-malarial agent. Pyronaridine tetraphosphate is active against P. falciparum and Echinococcus granulosus infection[2][3].

For research use only. We do not sell to patients.

Pyronaridine-d<sub>4</sub> tetraphosphate Chemical Structure

Pyronaridine-d₄ tetraphosphate Chemical Structure

CAS No. : 1186026-25-4

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	Get quote
10 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Pyronaridine-d₄ tetraphosphate:

Pyronaridine tetraphosphate In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

914.06

Formula

C₂₉H₄₀D₄ClN₅O₁₈P₄

CAS No.

1186026-25-4

Unlabeled CAS

76748-86-2

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=P(O)(O)O.ClC1=CC2=C(C=C1)C(NC3=CC(C([2H])([2H])N4CCCC4)=C(C(C([2H])([2H])N5CCCC5)=C3)O)=C6C(C=CC(OC)=N6)=N2.O=P(O)(O)O.O=P(O)(O)O.O=P(O)(O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 25 mg/mL (27.35 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0940 mL	5.4701 mL	10.9402 mL
5 mM	0.2188 mL	1.0940 mL	2.1880 mL
10 mM	0.1094 mL	0.5470 mL	1.0940 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 97.00%

Select Batch:

Data Sheet (277 KB) SDS (252 KB)

COA (258 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

[2]. Vivas L, et al. Anti-malarial efficacy of pyronaridine and artesunate in combination in vitro and in vivo. Acta Trop. 2008 Mar;105(3):222-8. [Content Brief]

[3]. Jun Li, et al. Old drug repurposing for neglected disease: Pyronaridine as a promising candidate for the treatment of Echinococcus granulosus infections. EBioMedicine. 2020 Apr;54:102711. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.0940 mL	5.4701 mL	10.9402 mL	27.3505 mL
	5 mM	0.2188 mL	1.0940 mL	2.1880 mL	5.4701 mL
	10 mM	0.1094 mL	0.5470 mL	1.0940 mL	2.7351 mL
	15 mM	0.0729 mL	0.3647 mL	0.7293 mL	1.8234 mL
	20 mM	0.0547 mL	0.2735 mL	0.5470 mL	1.3675 mL
	25 mM	0.0438 mL	0.2188 mL	0.4376 mL	1.0940 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.