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  5. (R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone

(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone, a homoisoflavonoid, has antiangiogenic activity against human retinal microvascular endothelial cells.

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(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone Chemical Structure

(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone Chemical Structure

CAS No. : 849727-88-4

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(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone Related Antibodies

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Description

(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone, a homoisoflavonoid, has antiangiogenic activity against human retinal microvascular endothelial cells[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
> 100 μM
Compound: 18
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
[PMID: 19689125]
B16-BL6 IC50
> 100 μM
Compound: 18
Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay
Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay
[PMID: 19689125]
HeLa IC50
> 100 μM
Compound: 18
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
[PMID: 19689125]
HT-1080 IC50
> 100 μM
Compound: 18
Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay
Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay
[PMID: 19689125]
HT-29 IC50
> 20 μM
Compound: 7
Cytotoxicity against human HT-29 cells assessed as reduction in cell growth incubated for 72 hrs
Cytotoxicity against human HT-29 cells assessed as reduction in cell growth incubated for 72 hrs
[PMID: 26147490]
HUVEC GI50
> 100 μM
Compound: 7; 21
Antiproliferative activity against HUVEC assessed as reduction in cell number incubated for 44 hrs by alamar blue based fluorescence assay
Antiproliferative activity against HUVEC assessed as reduction in cell number incubated for 44 hrs by alamar blue based fluorescence assay
[PMID: 30951308]
MDA-MB-435 IC50
> 20 μM
Compound: 7
Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell growth incubated for 72 hrs
Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell growth incubated for 72 hrs
[PMID: 26147490]
Y79 GI50
> 100 μM
Compound: 7; 21
Cytotoxicity against human Y79 cells assessed as reduction in cell number incubated for 44 hrs by alamar blue based fluorescence assay
Cytotoxicity against human Y79 cells assessed as reduction in cell number incubated for 44 hrs by alamar blue based fluorescence assay
[PMID: 30951308]
In Vitro

(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone has an GI50 value of 35.8 μM on proliferation of human retinal microvascular endothelial cells (HRECs)[1].
(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone (10 μM, 30 μM, and 100 μM; 8 hours) significantly decreases HRECs overall tubule formation and in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone Related Antibodies
Molecular Weight

286.28

Formula

C16H14O5
CAS No.
SMILES

O=C1[C@H](CC2=CC=C(O)C=C2)COC3=CC(O)=CC(O)=C13
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone849727-88-4OthersInhibitorinhibitorinhibit

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(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone
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