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  4. (R)-FTY 720P

(R)-FTY 720P is the R-isomer of FTY 720P. (R)-FTY 720P has less potent binding affinities to S1P1,3,4,5 than (S)-Isomer (HY-15382).

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(R)-FTY 720P Chemical Structure

(R)-FTY 720P Chemical Structure

CAS No. : 402616-23-3

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Based on 1 publication(s) in Google Scholar

(R)-FTY 720P Related Antibodies

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Description

(R)-FTY 720P is the R-isomer of FTY 720P. (R)-FTY 720P has less potent binding affinities to S1P1,3,4,5 than (S)-Isomer (HY-15382)[1].

Cellular Effect
Cell Line Type Value Description References
CHO EC50
> 10000 nM
Compound: (rac)-5
Agonism of human S1P-2 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
Agonism of human S1P-2 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
[PMID: 16078855]
CHO EC50
0.005 nM
Compound: 1-P; FTY-P
Agonist activity at human S1P1 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by HTRF analysis
Agonist activity at human S1P1 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by HTRF analysis
[PMID: 26985316]
CHO EC50
0.0056 nM
Compound: 1-P; FTY-P
Agonist activity at human S1P1 receptor expressed in CHO cells assessed as ERK phosphorylation after 7 mins by alphaLISA
Agonist activity at human S1P1 receptor expressed in CHO cells assessed as ERK phosphorylation after 7 mins by alphaLISA
[PMID: 26985316]
CHO IC50
0.014 nM
Compound: 1-P; FTY-P
Displacement of 33-P-S1P from from human S1P receptor expressed in CHO cell membranes after 50 mins by scintillation counting
Displacement of 33-P-S1P from from human S1P receptor expressed in CHO cell membranes after 50 mins by scintillation counting
[PMID: 26985316]
CHO EC50
0.07 nM
Compound: 1-P; FTY-P
Agonist activity at human S1P1 receptor expressed in CHO cells co-expressing GFP assessed as cellular internalization after 45 mins by Hoechst assay
Agonist activity at human S1P1 receptor expressed in CHO cells co-expressing GFP assessed as cellular internalization after 45 mins by Hoechst assay
[PMID: 26985316]
CHO EC50
0.3 nM
Compound: 2
Activity at human S1P1 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
Activity at human S1P1 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
[PMID: 15615513]
CHO EC50
1.2 nM
Compound: (rac)-5
Agonism of human S1P-1 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
Agonism of human S1P-1 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
[PMID: 16078855]
CHO EC50
1.4 nM
Compound: (rac)-5
Agonism of human S1P-3 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
Agonism of human S1P-3 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
[PMID: 16078855]
CHO EC50
11 nM
Compound: FTY720-phosphate
Agonist activity at S1P5 receptor (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation by GTPgammaS binding assay
Agonist activity at S1P5 receptor (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation by GTPgammaS binding assay
[PMID: 26509640]
CHO EC50
14 nM
Compound: 3, FTY-720P
Agonist activity at S1P1 receptor (unknown origin) expressed in CHO cells preincubated for 2 hrs followed by D2-labeled IP1 and Ab-Cryp addition measured after 1 hr by fluorescence assay
Agonist activity at S1P1 receptor (unknown origin) expressed in CHO cells preincubated for 2 hrs followed by D2-labeled IP1 and Ab-Cryp addition measured after 1 hr by fluorescence assay
10.1039/C3MD00079F
CHO EC50
2.4 nM
Compound: (rac)-5
Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
[PMID: 16078855]
CHO EC50
3.4 nM
Compound: FTY720-phosphate
Agonist activity at S1P5 receptor (unknown origin) expressed in CHO cell membranes after 30 mins by GTPgammaS binding assay
Agonist activity at S1P5 receptor (unknown origin) expressed in CHO cell membranes after 30 mins by GTPgammaS binding assay
[PMID: 26509640]
CHO EC50
35.1 nM
Compound: 3, FTY720-P
Agonist activity at human S1P3 receptor expressed in CHO cells preincubated for 2 hrs before IP1 addition by IP1-HTRF assay
Agonist activity at human S1P3 receptor expressed in CHO cells preincubated for 2 hrs before IP1 addition by IP1-HTRF assay
[PMID: 25072873]
CHO EC50
4.9 nM
Compound: (rac)-5
Agonism of human S1P-5 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
Agonism of human S1P-5 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
[PMID: 16078855]
CHO EC50
44 nM
Compound: 3, FTY-720P
Agonist activity at S1P3 receptor (unknown origin) expressed in CHO cells preincubated for 2 hrs followed by D2-labeled IP1 and Ab-Cryp addition measured after 1 hr by fluorescence assay
Agonist activity at S1P3 receptor (unknown origin) expressed in CHO cells preincubated for 2 hrs followed by D2-labeled IP1 and Ab-Cryp addition measured after 1 hr by fluorescence assay
10.1039/C3MD00079F
CHO EC50
9.1 nM
Compound: 3, FTY720-P
Agonist activity at human S1P1 receptor expressed in CHO cells preincubated for 2 hrs before IP1 addition by IP1-HTRF assay
Agonist activity at human S1P1 receptor expressed in CHO cells preincubated for 2 hrs before IP1 addition by IP1-HTRF assay
[PMID: 25072873]
HEK-293T EC50
0.1 nM
Compound: FTY720-P
Activity at human S1P3 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
Activity at human S1P3 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
[PMID: 17113298]
HEK-293T EC50
1.3 nM
Compound: FTY720-P
Activity at human S1P1 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
Activity at human S1P1 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
[PMID: 17113298]
HEK-293T EC50
4 nM
Compound: FTY720-P
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
[PMID: 17113298]
HEK-293T EC50
4 nM
Compound: FTY720-P
Activity at human S1P5 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
Activity at human S1P5 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
[PMID: 17113298]
In Vivo

(R)-FTY 720P (intravenous bolus administration ) has no clear effect on heart rate up to a dose of 0.3mg/kg in anesthetized rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

387.45

Formula

C19H34NO5P
CAS No.
SMILES

OC[C@@](CCC1=CC=C(CCCCCCCC)C=C1)(N)COP(O)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(R)-FTY 720P Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-FTY 720P402616-23-3OthersR-isomerFTY 720PInhibitorinhibitorinhibit

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