2. Metabolic Enzyme/Protease
  3. PCSK9
  4. (R,R)-PCSK9 degrader 1

(R,R)-PCSK9 degrader 1 is the isomer of PCSK9 degrader 1 (HY-130245). PCSK9 degrader 1 (Compound 16) is a small molecule ligand for proprotein convertase substilisin-like/kexin type 9 (PCSK9) and shows high affinity to PCSK9 with a Ki of 107 nM. PCSK9 degrader 1 can involve in a protein-protein interaction with the low-density lipoprotein (LDL) receptor.

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(R,R)-PCSK9 degrader 1 Chemical Structure

(R,R)-PCSK9 degrader 1 Chemical Structure

CAS No. : 2216703-12-5

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(R,R)-PCSK9 degrader 1 Related Antibodies

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Description

(R,R)-PCSK9 degrader 1 is the isomer of PCSK9 degrader 1 (HY-130245). PCSK9 degrader 1 (Compound 16) is a small molecule ligand for proprotein convertase substilisin-like/kexin type 9 (PCSK9) and shows high affinity to PCSK9 with a Ki of 107 nM. PCSK9 degrader 1 can involve in a protein-protein interaction with the low-density lipoprotein (LDL) receptor[1].

Molecular Weight

1077.22

Formula

C53H69FN8O13S
CAS No.
SMILES

OC(C(C=C1)=CC=C1C(C(F)=C2)=CC=C2OC(C(OCCOCCNC([C@H](NC(OC(C)(C)C)=O)CCCN/C(NC(OC(C)(C)C)=O)=N/C(OC(C)(C)C)=O)=O)=C3)=CC4=C3CCN[C@]4(C)CC(NC5=NC=CS5)=O)=O
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(R,R)-PCSK9 degrader 1 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R,R)-PCSK9 degrader 12216703-12-5PCSK9Proprotein convertase subtilisin/kexin type 9Inhibitorinhibitorinhibit

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HY-130245A
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