(R,R)-THC

Cat. No.: HY-103451 Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

(R,R)-THC is an ERα agonist and an ERβ antagonist, with K_is of 9.0 nM and 3.6 nM for ERα and ERβ, respectively. (R,R)-THC has higher relative binding affinity for ERβ than ERα with the values of 25 and 3.6.

For research use only. We do not sell to patients.

(R,R)-THC Chemical Structure

CAS No. : 221368-54-3

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5 mg		Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

Other Forms of (R,R)-THC:

rel-(R,R)-THC Get quote

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View All Estrogen Receptor/ERR Isoform Specific Products:

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

ERα

9.0 nM (Ki)

ERβ

3.6 nM (Ki)

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	EC₅₀	8.6 μM Compound: 14	Agonist activity at PXR (unknown origin) expressed in human HepG2 cells assessed as induction of CYP3A4 transactivation after 16 hrs by luciferase reporter gene assay Agonist activity at PXR (unknown origin) expressed in human HepG2 cells assessed as induction of CYP3A4 transactivation after 16 hrs by luciferase reporter gene assay	[PMID: 23688559]

Molecular Weight

320.42

Formula

C₂₂H₂₄O₂

CAS No.

221368-54-3

Appearance

Solid

Color

Light yellow to brown

SMILES

OC(C=C1C[C@H]2CC)=CC=C1C3=C2C4=C(C=C(O)C=C4)C[C@H]3CC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (267 KB) SDS (251 KB)

COA (248 KB) Elemental Analysis Report (106 KB)

Handling Instructions (2659 KB)

References

[1]. Sun J, et al. Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-alpha or estrogen receptor-beta. Endocrinology. 1999;140(2):800-804. [Content Brief]

(R,R)-THC Related Classifications

Metabolic Disease

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R,R)-THC221368-54-3Estrogen Receptor/ERRTetrahydrochryseneRelative binding affinityInhibitorinhibitorinhibit

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