(±)11(12)-EET (Synonyms: 11,12-EET)

Name: (±)11(12)-EET
Brand: MedChemExpress
SKU: HY-130494
Rating: 4.5 (1 reviews)

Cat. No.: HY-130494 Purity: 98.3%: FAQs
Data Sheet SDS COA Handling Instructions

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(±)11(12)-EET is a NLRP3 inflammasome inhibitor. (±)11(12)-EET can be used for the research of anti-inflammatory, angiogenic and cardioprotective.

For research use only. We do not sell to patients.

(±)11(12)-EET Chemical Structure

CAS No. : 87173-81-7

Size	Price	Stock	Quantity
Solvent
25μg（312.04 μM * 250 μL in Ethanol）	USD 120	In-stock	Estimated Time of Arrival: December 31
Solvent
50μg（312.04 μM * 500 μL in Ethanol）	USD 200	In-stock	Estimated Time of Arrival: December 31

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Based on 1 publication(s) in Google Scholar

Other Forms of (±)11(12)-EET:

(±)11(12)-EET-d₁₁ Get quote

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Description

(±)11(12)-EET is a NLRP3 inflammasome inhibitor. (±)11(12)-EET can be used for the research of anti-inflammatory, angiogenic and cardioprotective^[1]^[2]^[3]^[4]^[6].

IC₅₀ & Target^[1]

NLRP3 inflammasome

In Vitro

(±)11(12)-EET (5 μM; 10 mimutes; macrophages) depresses NLRP3 protein expression, dramatically decreases the expression of pro-IL-1β in cells and the supernatant and reduces the intracellular ROS^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	Macrophages
Concentration:	5 μM
Incubation Time:	10 mimutes
Result:	Depresses NLRP3 protein expression.

Immunofluorescence^[1]

Cell Line:	Macrophages
Concentration:	5 μM
Incubation Time:	10 mimutes
Result:	Reduced the intracellular ROS.

In Vivo

(±)11(12)-EET increases adhesion of isolated peripheral blood leukocytes in a chamber coated with P-selectin and ICAM-1 in 50 μg/kg^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

320.47

Formula

C₂₀H₃₂O₃

CAS No.

87173-81-7

Appearance

Liquid

Color

Colorless to light yellow

SMILES

CCCCC/C=C\C[C@H]1O[C@H]1C/C=C\C/C=C\CCCC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Solution, -20°C, 2 years

Purity & Documentation

Purity: 98.3%

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Data Sheet (271 KB) SDS (251 KB)

COA (247 KB)

Handling Instructions (2659 KB)

References

[1]. Luo XQ, et al. Epoxyeicosatrienoic acids inhibit the activation of NLRP3 inflammasome in murine macrophages. J Cell Physiol. 2020;235(12):9910-9921. [Content Brief]

[2]. Chacos N, et al. Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid. Biochem Biophys Res Commun. 1982;104(3):916-922. [Content Brief]

[3]. Oliw EH, et al. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. J Biol Chem. 1982;257(7):3771-3781. [Content Brief]

[4]. Capdevila JH, et al. Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase. J Lipid Res. 2000;41(2):163-181. [Content Brief]

[5]. Wang Z, et al. Arachidonic acid inhibits basolateral K channels in the cortical collecting duct via cytochrome P-450 epoxygenase-dependent metabolic pathways. Am J Physiol Renal Physiol. 2008;294(6):F1441-F1447. [Content Brief]

[6]. Spector AA. Arachidonic acid cytochrome P450 epoxygenase pathway. J Lipid Res. 2009;50 Suppl(Suppl):S52-S56. [Content Brief]

(±)11(12)-EET Related Classifications

Inflammation/Immunology Cardiovascular Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(±)11(12)-EET87173-81-711,12-EETNOD-like Receptor (NLR)inflammasomeR/SenantiomericarachidoniccytochromeP450anti-inflammatoryangiogenicInhibitorinhibitorinhibit

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(±)11(12)-EET (Synonyms: 11,12-EET)

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