RBP4 ligand-1 

RBP4 ligand-1 is a non-retinoid ligands for (RBP4) retinol-binding protein 4. The hRBP4_SPA IC₅₀ and RBP4–TTR FRET IC₅₀ values are 0.23±0.11 and 0.13±0.12 μM in the radioligand binding assay and FRET assay, respectively^[1].

Retinol-Binding Protein 4 (RBP4) is a physiological carrier of retinol (vitamin A) in blood, delivering retinol from the liver to peripheral tissues.RBP4 ligand-1 has the ability to disrupt the RBP4–TTR protein–protein interaction (hRPB4–TTR). The RBP4–TTR FRET IC₅₀ is 0.13±0.12 μM in FRET assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RBP4配体

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

414.81

C₁₈H₁₈ClF₃N₄O₂

260553-24-0

FC(F)(C1=C(N2CCN(C(NC3=C(C=CC(Cl)=C3)OC)=O)CC2)N=CC=C1)F

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• [1]. Yingcai Wang, et al. Structure-assisted discovery of the first non-retinoid ligands for Retinol-Binding Protein 4. Bioorg Med Chem Lett. 2014 Jul 1;24(13):2885-91.  [Content Brief]