1. Recombinant Proteins
  2. Enzymes & Regulators
  3. Transferases (EC 2) Serine/Threonine Kinase Proteins
  4. AKT Serine/Threonine Kinase 3 (AKT3)
  5. AKT3 Protein, Human (Active, sf9, GST)

The AKT3 protein, like AKT1 and AKT2, is an important member of the AKT kinase family and plays a central role in a variety of cellular processes, including metabolism, proliferation, survival, growth, and angiogenesis. AKT3 has more than 100 reported targets and coordinates complex signaling pathways that control glucose uptake, regulate glycogen storage, and influence neurogenesis. AKT3 Protein, Human (Active, sf9, GST) is the recombinant human-derived AKT3, expressed by Sf9 insect cells , with GST labeled tag. The total length of AKT3 Protein, Human (Active, sf9, GST) is 479 a.a.,

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Description

The AKT3 protein, like AKT1 and AKT2, is an important member of the AKT kinase family and plays a central role in a variety of cellular processes, including metabolism, proliferation, survival, growth, and angiogenesis. AKT3 has more than 100 reported targets and coordinates complex signaling pathways that control glucose uptake, regulate glycogen storage, and influence neurogenesis. AKT3 Protein, Human (Active, sf9, GST) is the recombinant human-derived AKT3, expressed by Sf9 insect cells , with GST labeled tag. The total length of AKT3 Protein, Human (Active, sf9, GST) is 479 a.a.,

Background

AKT2, a crucial member of the AKT kinase family along with AKT1 and AKT3, orchestrates a myriad of cellular processes, including metabolism, proliferation, cell survival, growth, and angiogenesis. Operating through the phosphorylation of numerous downstream substrates, AKT2 influences over 100 reported targets, exhibiting remarkable functional diversity. It governs insulin-induced glucose uptake by facilitating SLC2A4/GLUT4 translocation and intricately regulates insulin signaling pathways. Additionally, AKT2 modulates glycogen storage, inhibits GSK3 kinase activity, and plays a pivotal role in the AKT-mTOR signaling pathway, influencing neurogenesis and cellular migration dynamics. AKT2's involvement in phosphorylating FOXO factors, CREB1, and multiple targets related to metabolism underscores its pivotal position in cellular homeostasis. Notably, AKT2 exhibits isoform-specific functions, with a significant role in regulating glucose uptake and participating in intricate processes such as skeletal muscle differentiation. The recent identification of specific substrates like PITX2 and ANKRD2 further delineates AKT2's nuanced and intricate cellular regulatory roles.

Species

Human

Source

Sf9 insect cells

Tag

GST

Accession

Q9Y243-1 (M1-E479)

Gene ID

10000

Synonyms
AKT3; AKT serine/threonine kinase 3; MPPH; PKBG; MPPH2; PRKBG; STK-2; PKB-GAMMA; RAC-gamma; RAC-PK-gamma; RAC-gamma serine/threonine-protein kinase; PKB gamma; RAC-gamma serine/threonine protein kinase; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma); EC 2.7.11.1
Purity

Greater than 80 % as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
AKT3 Protein, Human (Active, sf9, GST)
Cat. No.:
HY-P702633
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