Alpha-2-Antiplasmin/Serpin F2 Protein, Cynomolgus (HEK293, His)

Alpha-2-antiplasmin/serpin F2 protein is a member of the serine protease inhibitor family and can significantly inhibit plasmin to regulate thrombolysis. Synthesized in the liver and circulating in the blood, it prevents excessive fibrinolysis and ensures clot stabilization. Alpha-2-Antiplasmin/Serpin F2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Alpha-2-Antiplasmin/Serpin F2 protein, expressed by HEK293 , with C-His labeled tag. The total length of Alpha-2-Antiplasmin/Serpin F2 Protein, Cynomolgus (HEK293, His) is 464 a.a., with molecular weight of 60-70 kDa.

The Alpha-2-Antiplasmin/Serpin F2 Protein belongs to the serpin family, a group of proteins that regulate protease activity. It plays a crucial role in inhibiting plasmin, a protease involved in blood clot dissolution. By inhibiting plasmin, Alpha-2-Antiplasmin/Serpin F2 prevents excessive fibrinolysis and helps maintain the stability of blood clots. This protein is primarily synthesized in the liver and circulates in the blood. Deficiencies or dysregulation of Alpha-2-Antiplasmin/Serpin F2 can lead to increased fibrinolysis and a higher risk of bleeding disorders. Additionally, this protein has been implicated in other biological processes, such as inflammation and tissue remodeling. A deeper understanding of the function and regulation of Alpha-2-Antiplasmin/Serpin F2 can provide insights into the development of therapies for clotting disorders and other conditions involving abnormal protease activity.

1.Immobilized Cynomolgus SERPINF2, His Tag at 1 μg/mL (100 μl/Well) on the plate. Dose response curve for Anti-SERPINF2 Antibody, hFc Tag with the EC₅₀ of ≤1 μg/mL determined by ELISA.
2.Immobilized Cynomolgus SERPINF2, His Tag at 2 μg/mL (100 μl/Well) on the plate. Dose response curve for Anti-SERPINF2 Antibody, hFc Tag with the EC₅₀ of ≤55 ng/mL determined by ELISA.

Cynomolgus

HEK293

C-His

A0A2K5WNU6 (M27-K490)

102116557

60-70 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.