Apolipoprotein H/APOH Protein, Cynomolgus (HEK293, His)

Apolipoprotein H/APOH proteins have multiple functions and can bind to negatively charged substances such as heparin and phospholipids. Its diverse interactions highlight the adaptability that is critical for preventing activation of the intrinsic coagulation cascade by binding to phospholipids on the surface of damaged cells. Apolipoprotein H/APOH Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Apolipoprotein H/APOH protein, expressed by HEK293 , with C-His labeled tag. The total length of Apolipoprotein H/APOH Protein, Cynomolgus (HEK293, His) is 326 a.a., with molecular weight of 50-65 kDa.

The Apolipoprotein H/APOH protein exhibits versatile functionality as it binds to various negatively charged substances, including heparin, phospholipids, and dextran sulfate. Its interactions with these substances suggest a broad spectrum of molecular engagements, highlighting its adaptability. Notably, Apolipoprotein H/APOH may play a crucial role in preventing the activation of the intrinsic blood coagulation cascade by specifically binding to phospholipids present on the surface of damaged cells. This functionality underscores its potential contribution to the regulation of coagulation processes and its importance in maintaining hemostatic balance in response to cellular damage.

Immobilized Cynomolgus APOH, His Tag at 1 μg/mL (100 μl/well) on the plate. Dose response curve for Anti-APOH Antibody, hFc Tag with the EC₅₀ of ≤65 ng/mL determined by ELISA.

Cynomolgus

HEK293

C-His

XP_045230479.1 (G20-C345)

102134518  [NCBI]

50-65 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS, 100mM Arginine, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.