2. Recombinant Proteins
  3. Immune Checkpoint Proteins
  4. Stimulatory Immune Checkpoint Molecules
  5. B7-H6
  6. B7-H6 Protein, Cynomolgus (HEK293, Fc)

B7-H6 Protein, Cynomolgus (HEK293, Fc)

Cat. No.: HY-P76742
Handling Instructions

B7-H6 Protein is a member of B7 family that serves as a trigger for NCR3-dependent natural killer (NK) cell activation. Operating as a monomer, B7-H6 exhibits a specific interaction with NCR3, distinctly avoiding engagement with other NK cell-activating receptors. In addition, B7-H6 promotes tumorigenesis via apoptosis inhibition, proliferation and immunological progression. B7-H6 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived B7-H6 protein, expressed by HEK293 , with C-hFc labeled tag.

For research use only. We do not sell to patients.

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Description

B7-H6 Protein is a member of B7 family that serves as a trigger for NCR3-dependent natural killer (NK) cell activation. Operating as a monomer, B7-H6 exhibits a specific interaction with NCR3, distinctly avoiding engagement with other NK cell-activating receptors. In addition, B7-H6 promotes tumorigenesis via apoptosis inhibition, proliferation and immunological progression. B7-H6 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived B7-H6 protein, expressed by HEK293 , with C-hFc labeled tag.
Background

B7-H6, a member of B7 family, serves as a trigger for NCR3-dependent natural killer (NK) cell activation. Operating as a monomer, B7-H6 exhibits a specific interaction with NCR3, distinctly avoiding engagement with other NK cell-activating receptors, such as NCR1, NCR2, and KLRK1. This interaction highlights its unique role in initiating NK cell responses through the NCR3 pathway, showcasing its specificity in the intricate network of NK cell activation mechanisms. B7-H6 has unique immunogenic properties, is a ligand of NKp30, which is an activating receptor of natural killer (NK) cells. High expression of B7-H6 is found in certain types of tumor cells, such as lymphoma, leukemia and gastric carcinoma. The expression of B7-H6 can be induced by inflammatory stress in healthy cells. In addition, B7‐H6 enhances the initiation of “caspase cascades” and anti-apoptosis role to provoke tumorigenesis via the STAT3 activation. B7‐H6 promotes tumor proliferation and G0/G1 cycle process by regulating the downstream apoptosis suppressors survivin, Mcl‐1, Bcl‐2, and Bcl‐xL. It induces cellular cytotoxicity, TNF-α and IFN-γ secretion by mediating IL-6 expression and B7-H6-specific BiTE triggers T cell to facilitate tumorigenesis. All these molecular mechanisms are involved in B7-H6-induced tumorigenesis[1].
Species

Cynomolgus
Source

HEK293
Tag

C-hFc
Accession

XP_005578557 (D25-D259)
Gene ID
Molecular Construction
N-term
B7-H6 (D25-D259)
Accession # XP_005578557
hFc
C-term
Synonyms
Natural cytotoxicity triggering receptor 3 ligand 1; B7-H6; NCR3LG1
Molecular Weight

Approximately 53.2 kDa.
Purity

Greater than 90% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

B7-H6 Protein, Cynomolgus (HEK293, Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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