Bcl-2-like protein 1 Protein, Human (His)

Bcl-2-like protein 1 Protein, Human (His) is an important apoptosis regulating gene that codes for both an anti-apoptotic (Bcl-x_L) and a pro-apoptotic (Bcl-x_S) splice variant^[1].

BCL2L1 is functionally involved in several cancer-related processes and its protein expression is associated with 20q gain. BCL2L1 (BCL2-like 1) belongs to the family of Bcl-2 proteins that are involved in the regulation of the mitochondrial pathway of apoptosis by controlling the release of proapoptotic factors from the mitochondrion^[1].

Human

E. coli

C-6*His

Q07817 (M1-R212)

598  [NCBI]

MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRHHHHHH

Approximately 29.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.2 μm filter solution of 20 mM HEPES, 50 mM KCl, 20% Glycerol, pH 7.5.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.

• [1]. Anke H Sillars-Hardebol, et al. BCL2L1 has a functional role in colorectal cancer and its protein expression is associated with chromosome 20q gain. J Pathol. 2012 Feb;226(3):442-50.  [Content Brief]