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  3. BRPF1 Protein, Human (115a.a)

BRPF1 Protein, Human (115a.a)

Cat. No.: HY-P703595
Handling Instructions

The BRPF1 protein is a key scaffold in HAT complexes such as MOZ/MORF and HBO1, and has histone H3 acetyltransferase activity. In the HBO1 complex, BRPF1 directs the specificity of KAT7/HBO1 for H3K14ac. BRPF1 Protein, Human (115a.a) is the recombinant human-derived BRPF1, expressed by E. coli , with tag Free labeled tag. The total length of BRPF1 Protein, Human (115a.a) is 115 a.a.,

For research use only. We do not sell to patients.

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Description

The BRPF1 protein is a key scaffold in HAT complexes such as MOZ/MORF and HBO1, and has histone H3 acetyltransferase activity. In the HBO1 complex, BRPF1 directs the specificity of KAT7/HBO1 for H3K14ac. BRPF1 Protein, Human (115a.a) is the recombinant human-derived BRPF1, expressed by E. coli , with tag Free labeled tag. The total length of BRPF1 Protein, Human (115a.a) is 115 a.a.,

Background

BRPF1, a pivotal scaffold subunit of histone acetyltransferase (HAT) complexes, such as MOZ/MORF and HBO1, exhibits histone H3 acetyltransferase activity. Within the HBO1 complex, BRPF1 plays a crucial role in directing the specificity of KAT7/HBO1 towards acetylation of histone H3 at 'Lys-14' (H3K14ac). Some HAT complexes, in which BRPF1 participates, preferentially mediate acetylation at histone H3 'Lys-23' (H3K23ac). Beyond its catalytic role, BRPF1 positively regulates the transcription of key genes like RUNX1 and RUNX2. It functions as a key component in the assembly of the HBO1 complex, interacting with KAT7/HBO1, MEAF6, and ING5. Additionally, BRPF1 is integral to the MOZ/MORF complex, collaborating with ING5, KAT6A, KAT6B, and MEAF6. The interaction of BRPF1 with specific histone modifications, such as unmethylated H3 at 'Lys-4' (H3K4me0) and trimethylated 'Lys-36' of histone H3 (H3K36me3), underscores its intricate involvement in chromatin dynamics. Notably, BRPF1 interacts with KAT7, highlighting its association with key players in HAT complexes and emphasizing its multifaceted role in epigenetic regulation.

Species

Human

Source

E. coli

Tag

Tag Free

Accession

P55201-1 (M626-G740)

Gene ID

7862

Synonyms
BR140
Molecular Weight

Approximately 13.7 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

BRPF1 Protein, Human (115a.a) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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BRPF1 Protein, Human (115a.a)
Cat. No.:
HY-P703595
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