Cadherin-17 Protein, Cynomolgus (HEK293, His)

Cadherin-17 Protein, a member of the calcium-dependent cell adhesion protein family, assumes a crucial role in mediating cellular adhesion. Employing preferential homophilic interactions, Cadherin-17 facilitates self-binding between connecting cells. With its calcium-dependent adhesion properties, Cadherin-17 actively participates in establishing selective connections between cells, influencing the dynamic regulation of cellular interactions and contributing to the overall structural integrity of tissues, particularly in the liver and intestine. Cadherin-17 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Cadherin-17 protein, expressed by HEK293 , with C-His labeled tag.

Cadherin-17, a member of the calcium-dependent cell adhesion protein family, assumes a crucial role in mediating cellular adhesion. Employing preferential homophilic interactions, Cadherin-17 facilitates self-binding between connecting cells. This homophilic cadherin engagement underscores its significance in cell adhesion and suggests a substantial contribution to the intricate process of sorting heterogeneous cell types. Additionally, Cadherin-17, also known as LI-cadherin, may play a role in the morphological organization of the liver and intestine, indicating its involvement in the structural organization of these tissues. With its calcium-dependent adhesion properties, Cadherin-17 actively participates in establishing selective connections between cells, influencing the dynamic regulation of cellular interactions and contributing to the overall structural integrity of tissues, particularly in the liver and intestine^[1].

Immobilized Cynomolgus CDH17, His Tag at 0.5 μg/mL (100 μl/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC₅₀ of ≤ 8 ng/mL determined by ELISA.

Cynomolgus

HEK293

C-His

XP_005563762.2 (Q23-T784)

102129651  [NCBI]

95-115 kDa

Greater than 95% as determined by Tris-Bis PAGE

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS, PH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.