CADM4/IGSF4C Protein, Human (HEK293, His)

CADM4/IGSF4C Protein is crucial for calcium- and magnesium-independent cell-cell adhesion, actively mediating cellular interactions. Apart from its adhesive role, it is speculated to act as a tumor suppressor, hinting at a potential regulatory role in cell growth and tumorigenic processes. The dual attributes of mediating adhesion and potentially suppressing tumors highlight the multifaceted nature of CADM4/IGSF4C in cellular processes. CADM4/IGSF4C Protein, Human (HEK293, His) is the recombinant human-derived CADM4/IGSF4C protein, expressed by HEK293 , with C-His labeled tag.

The CADM4/IGSF4C Protein plays a crucial role in cell-cell adhesion, demonstrating calcium- and magnesium-independent adhesion activity. This protein, with its monomeric and homodimeric forms, actively participates in mediating cellular interactions. Beyond its adhesive functions, CADM4/IGSF4C is speculated to possess tumor-suppressor activity, suggesting a potential role in regulating cell growth and suppressing tumorigenic processes. The dual attributes of mediating cell-cell adhesion and potentially exerting tumor-suppressive effects underscore the multifaceted nature of CADM4/IGSF4C in cellular processes.

Measured by its ability to inhibit the proliferation of A549 cells. The ED₅₀ for this effect is 0.4653 μg/mL, corresponding to a specific activity is 2.149×10³ units/mg.

• 
  Measured by its ability to inhibit the proliferation of A549 cells. The ED₅₀ for this effect is 0.4653 μg/mL, corresponding to a specific activity is 2.149×10³ units/mg.

Human

HEK293

C-6*His

Q8NFZ8 (P21-Y323)

199731  [NCBI]

PGAGQEVQTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQLEEFSPRRVRIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVEVREQAVEGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQTSVPY

Approximately 48-70 kDa.

• 
  Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4, 8% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.