1. Recombinant Proteins
  2. Immune Checkpoint Proteins Receptor Proteins
  3. Stimulatory Immune Checkpoint Molecules
  4. CD200R
  5. CD200R2
  6. CD200R1L Protein, Human (HEK293, His)

CD200R1L Protein, Human (HEK293, His)

Cat. No.: HY-P77319
SDS COA Handling Instructions

The CD200R1L protein is a potential receptor for the CD200/OX2 cell surface glycoprotein and has been shown to play a role in mediating cellular responses associated with CD200 signaling. As a receptor, CD200R1L may engage in complex interactions with CD200, contributing to immune regulation and cellular communication. CD200R1L Protein, Human (HEK293, His) is the recombinant human-derived CD200R1L protein, expressed by HEK293 , with C-His labeled tag.

For research use only. We do not sell to patients.

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  • Biological Activity

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Description

The CD200R1L protein is a potential receptor for the CD200/OX2 cell surface glycoprotein and has been shown to play a role in mediating cellular responses associated with CD200 signaling. As a receptor, CD200R1L may engage in complex interactions with CD200, contributing to immune regulation and cellular communication. CD200R1L Protein, Human (HEK293, His) is the recombinant human-derived CD200R1L protein, expressed by HEK293 , with C-His labeled tag.

Background

CD200R1L Protein appears to function as a potential receptor for the CD200/OX2 cell surface glycoprotein. This designation suggests a role in mediating cellular responses associated with CD200 signaling. As a receptor, CD200R1L likely participates in the intricate interactions between CD200 and its binding partner, contributing to the modulation of immune responses and cell communication. Exploring the specific mechanisms and downstream effects of CD200R1L's interaction with CD200/OX2 could deepen our understanding of its role in immune regulation and cellular processes, offering insights into its potential implications in health and disease.

Biological Activity

Measured by its binding ability in a functional ELISA. When Recombinant Human CD200 (HY-P70476) is Immobilized at 2 μg/mL (100 µL/well) can bind Human CD200R1L. The ED50 for this effect is 1.605 μg/mL.

  • Measured by its binding ability in a functional ELISA. When Recombinant Human CD200 (HY-P70476) is Immobilized at 2 μg/mL (100 µL/well) can bind Human CD200R1L. The ED50 for this effect is 1.605 μg/mL.
Species

Human

Source

HEK293

Tag

C-6*His

Accession

Q6Q8B3-1 (G24-L239)

Gene ID
Molecular Construction
N-term
CD200R1L (M1-L239)
Accession # Q6Q8B3
His
C-term
Synonyms
Cell surface glycoprotein CD200 receptor 2; HuCD200R2; CD200RLa; CD200R1L; CD200R2
AA Sequence

GKQMTQNYSTIFAEGNISQPVLMDINAVLCCPPIALRNLIIITWEIILRGQPSCTKAYKKETNETKETNCTVERITWVSRPDQNSDLQIRPVDTTHDGYYRGIVVTPDGNFHRGYHLQVLVTPEVNLFQSRNITAVCKAVTGKPAAQISWIPEGSILATKQEYWGNGTVTVKSTCPWEGHKSTVTCHVSHLTGNKSLSVKLNSGLRTSGSPALSLL

Molecular Weight

Approximately 40-56 kDa due to the glycosylation.

Purity
  • Greater than 95% as determined by reducing SDS-PAGE.
Appearance

Lyophilized powder

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.0.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Documentation

CD200R1L Protein, Human (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
CD200R1L Protein, Human (HEK293, His)
Cat. No.:
HY-P77319
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