CD204/MSR1 Protein, Rat (HEK293, Fc)

CD204/MSR1 Protein is a homo-trimeric transmembrane glycoprotein, holds key inflammatory roles in multiple pathophysiologic processes. MSR1 is highly expressed in lung, arteries, and adipose tissue^[1]. CD204/MSR1 Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD204/MSR1 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of CD204/MSR1 Protein, Rat (HEK293, Fc) is 376 a.a., with molecular weight of ~89 kDa.

MSR1, also known as scavenger receptor-A (SR-A) or cluster of differentiation 204 (CD204), holds key inflammatory roles in multiple pathophysiologic processes. Present primarily on the surface of various types of macrophage, this receptor variably affects processes such as atherosclerosis, innate and adaptive immunity, lung and liver disease, and more recently, cancer. MSR1 has been shown to be important for M2 polarisation. Therefore, the role it carries or MSR1 is in part determined by the type of macrophage in which MSR1 is expressed and location within which the macrophages reside. The role of MSR1 is often dichotomous, being either host protective or detrimental to the pathogenesis of disease^[1].

Rat

HEK293

N-hFc

D3ZDS2 (W79-S454)

498638  [NCBI]

Approximately 89 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.