CD42a/GP9 Protein, Human (HEK293, Fc)

CD42a/GP9 protein, forming the GPIb-V-IX complex, acts as the von Willebrand factor (vWF) receptor, facilitating vWF-dependent platelet adhesion to blood vessels—a crucial step in arterial hemostasis. The GP-IX component contributes to the membrane insertion and orientation of GP-Ib, forming a non-covalent linkage with the GP-Ib heterodimer composed of two GP-Ib beta subunits and one GP-Ib alpha subunit. CD42a/GP9 Protein, Human (HEK293, Fc) is the recombinant human-derived CD42a/GP9 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD42a/GP9 Protein, Human (HEK293, Fc) is 131 a.a., with molecular weight of 48-52 kDa.

The CD42a/GP9 protein, also known as the GPIb-V-IX complex, plays a pivotal role as the von Willebrand factor (vWF) receptor, facilitating vWF-dependent platelet adhesion to blood vessels. This interaction is a crucial initial step in hemostasis, especially in response to injuries in the arterial circulation. GP-IX, within the GPIb-V-IX complex, is involved in the membrane insertion and orientation of GP-Ib. Notably, two GP-Ib beta subunits are disulfide-linked to one GP-Ib alpha subunit, and the GP-IX component forms a non-covalent linkage with the GP-Ib heterodimer.

Human

HEK293

C-hFc

P14770 (T17-G147)

2815  [NCBI]

48-52 kDa

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of 20 mM Tris, 250 mM NaCl, pH 8.5. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.