2. Recombinant Proteins
  3. Enzymes & Regulators
  4. Transferases (EC 2) Serine/Threonine Kinase Proteins
  5. Cyclin-Dependent Kinases (CDKs)
  6. CDK19-CCNC-MED12 Protein, Human (sf9, GST, Flag, His)

CDK19-CCNC-MED12 Protein, Human (sf9, GST, Flag, His)

Cat. No.: HY-P702699
Handling Instructions

CDK19 plays a key role in cellular homeostasis and developmental programming. CDK19 can interact with p53 to inhibit p53-mediated transcription of p21, and regulates the proliferation of hematopoietic stem cells and acute myeloid leukemia cells. Besides, CDK19 is the paralog of CDK8. CDK8 and CDK19 can cooperate with each other in stimulating NFκB-induced transcription and Dengue virus replication. CDK19-CCNC-MED12 Protein, Human (sf9, GST, Flag, His) is the recombinant human-derived CDK19-CCNC-MED12, expressed by Sf9 insect cells , with N-6*His, N-GST, N-Flag labeled tag. ,

For research use only. We do not sell to patients.

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Description

CDK19 plays a key role in cellular homeostasis and developmental programming. CDK19 can interact with p53 to inhibit p53-mediated transcription of p21, and regulates the proliferation of hematopoietic stem cells and acute myeloid leukemia cells. Besides, CDK19 is the paralog of CDK8. CDK8 and CDK19 can cooperate with each other in stimulating NFκB-induced transcription and Dengue virus replication[1][2][3]. CDK19-CCNC-MED12 Protein, Human (sf9, GST, Flag, His) is the recombinant human-derived CDK19-CCNC-MED12, expressed by Sf9 insect cells , with N-6*His, N-GST, N-Flag labeled tag. ,
Background

CDK19 is the paralog of CDK8. CDK19 plays a key role in cellular homeostasis and developmental programming[1]. CDK19 can interact with p53 to inhibit p53-mediated transcription of p21, and regulates the proliferation of hematopoietic stem cells and acute myeloid leukemia cells[2]. Besides, CDK8 and CDK19 can cooperate with each other in supporting leukemia cell growth, stimulating NFκB-induced transcription and Dengue virus replication[3].
Species

Human
Source

Sf9 insect cells
Tag

N-6*His;N-GST;N-Flag
Accession

Q9BWU1-1 (M1-Y502)&P24863-1 (M1-S283)&Q93074-1 (M1-D100)
Gene ID

23097&892&9968
Synonyms
CDC2L6; CDK19; cyclin dependent kinase 19; CDK11; CDC2L6; bA346C16.3; cyclin-dependent kinase 19; CDC2-related protein kinase 6; CDK8-like cyclin-dependent kinase; cell division cycle 2-like 6 (CDK8-like); cell division cycle 2-like protein kinase 6; cell division protein kinase 19; cyclin dependent kinase 19 variant 2; cyclin-dependent kinase (CDC2-like) 11; cyclin-dependent kinase 11; death-preventing kinase; EC 2.7.11.22
Molecular Weight

93.4 kDa & 36 kDa & 12.2 kDa
Purity

Greater than 90 % as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

CDK19-CCNC-MED12 Protein, Human (sf9, GST, Flag, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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