CSNK1A1 Protein, Human (sf9, His, Strep)

Casein kinase I α is a member of casein kinases that exhibits a preference for phosphorylation of acidic proteins such as casein. It phosphorylates many substrates, including CTNNB1 at "Ser-45" involved in Wnt signaling. CSNK1A1 Protein, Human (sf9, His, Strep) is the recombinant human-derived CSNK1A1, expressed by Sf9 insect cells , with Strep, His labeled tag. The total length of CSNK1A1 Protein, Human (sf9, His, Strep) is 336 a.a.,

Casein Kinase I alpha, a member of the casein kinase family, is characterized by its preference for acidic substrates such as caseins. Demonstrating versatility, it phosphorylates a diverse array of proteins and actively participates in Wnt signaling by phosphorylating CTNNB1 at 'Ser-45.' Additionally, Casein Kinase I alpha may contribute to the phosphorylation of PER1 and PER2, suggesting a potential role in circadian rhythm regulation. Beyond its involvement in cellular signaling pathways, this kinase may play a crucial role in chromosome segregation during mitosis and regulate epithelial cell migration by influencing keratin cytoskeleton disassembly. Furthermore, Casein Kinase I alpha acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrient stimuli, mediating the phosphorylation of the DEPTOR inhibitor. In another context, it functions as an inhibitor of NLRP3 inflammasome assembly through the phosphorylation of NLRP3, highlighting its diverse roles in cellular processes.

Human

Sf9 insect cells

Strep;His

P48729-1 (A2-F337)

1452

Greater than 80 % as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.