DSC2/Desmocollin-2 Protein, Human (HEK293, His)

DSC2/Desmocollin-2 protein is vital for intercellular desmosome junctions, mediating adhesion by interacting with plaque proteins and intermediate filaments. It also regulates cell positioning and interacts with DSP, PKP2, and JUP, strengthening junction stability. Overall, DSC2/Desmocollin-2 protein maintains tissue organization and functionality. DSC2/Desmocollin-2 Protein, Human (HEK293, His) is the recombinant human-derived DSC2/Desmocollin-2 protein, expressed by HEK293 , with C-His labeled tag. The total length of DSC2/Desmocollin-2 Protein, Human (HEK293, His) is 657 a.a., with molecular weight of ~85 & 100 KDa, respectively.

DSC2/Desmocollin-2 protein is a critical component of intercellular desmosome junctions, playing a crucial role in facilitating cell-cell adhesion by mediating the interaction between plaque proteins and intermediate filaments. In addition to its adhesive function, DSC2 may also contribute to epidermal cell positioning by regulating the adhesiveness between cells expressing different isoforms. This protein interacts with DSP, PKP2, and JUP, further reinforcing the stability and integrity of these junctions. By participating in these molecular interactions, DSC2/Desmocollin-2 protein ensures the proper organization and functionality of tissues.

Human

HEK293

C-His

Q02487 (A28-R684)

1824  [NCBI]

Approximately 85&100 kDa.

Greater than 90% as determined by reducing SDS-PAGE.

Solution

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.