DSG2/Desmoglein-2 Protein, Human (HEK293, His)

DSG2 is an important component of intercellular desmosome junctions and actively participates in complex interactions between plaque proteins and intermediate filaments, thereby promoting strong intercellular adhesion. By binding to these structural components, DSG-2 helps maintain cell cohesion and tissue integrity. DSG2/Desmoglein-2 Protein, Human (HEK293, His) is the recombinant human-derived DSG2/Desmoglein-2 protein, expressed by HEK293 , with C-His labeled tag.

Desmoglein-2 (DSG-2) is an essential component of intercellular desmosome junctions, playing a critical role in mediating cell-cell adhesion. Within these junctions, DSG-2 is involved in facilitating the interaction between plaque proteins and intermediate filaments, contributing to the structural integrity and stability of tissues. Notably, DSG-2 forms an interaction with Plakophilin-2 (PKP2), highlighting its involvement in the intricate molecular network responsible for desmosomal assembly and maintenance. This interaction underscores the significance of DSG-2 in ensuring proper cell adhesion and tissue cohesion, emphasizing its role as a key player in the regulation of intercellular connections in various tissues. (Reference: information provided)

Immobilized Human DSG-2 at 0.5 μg/mL (100μL/Well) on the plate. Dose response curve for Anti-DSG-2 Antibody with the EC₅₀ <19.5 ng/ml determined by ELISA.

Human

HEK293

C-His

Q14126 (A50-G609)

1829  [NCBI]

70-80 kDa

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized powder

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.