envelope glycoprotein gp64 Protein, AcmNPV (sf9, His)

Envelope glycoprotein gp64 is classified as a class III viral fusion protein. As an envelope phosphate glycoprotein, it promotes the fusion of virus and host endosomal membranes, thereby promoting virus entry into host cells. Following receptor-mediated viral internalization, gp64 undergoes a conformational change at low pH into a fusion-competent state, thereby releasing the nucleocapsid into the host cell cytoplasm upon cell fusion. envelope glycoprotein gp64 Protein, AcmNPV (sf9, His) is the recombinant Virus-derived envelope glycoprotein gp64 protein, expressed by Sf9 insect cells , with C-His labeled tag.

Envelope glycoprotein gp64 is a Class III viral fusion protein and a critical component of certain viruses. Serving as an envelope phosphoglycoprotein, gp64 plays a pivotal role in mediating the fusion between viral and host endosomal membranes, facilitating the entry of the virus into the host cell. Upon receptor-mediated internalization, gp64 undergoes a conformational change into a fusion-competent state at low pH, allowing the release of the viral nucleocapsid into the cytoplasm after cell fusion. Additionally, gp64 may be involved in the budding process. Structurally, gp64 forms homotrimers that are disulfide-linked, contributing to its stability and functionality in the viral fusion process (

Virus

Sf9 insect cells

C-His

P17501/NP_054158.1 (A21-T481)

1403961  [NCBI]

Approximately 54.2 kDa.

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.