ERK3 Protein, Human (L290V, His)

ERK3 Protein, an atypical MAPK, phosphorylates MAP2 and MAPKAPK5. Interacting with MAPKAPK5, ERK3/MAPK6 undergoes Ser-189 phosphorylation, facilitating MAPKAPK5 activation. Activated MAPKAPK5 reciprocally phosphorylates ERK3/MAPK6. The complex's precise functional implications, especially in cell cycle entry, remain elusive. ERK3 Protein, Human (L290V, His) is the recombinant human-derived ERK3 protein, expressed by E. coli , with N-6*His labeled tag.

ERK3, an atypical MAPK protein, exhibits the capacity to phosphorylate microtubule-associated protein 2 (MAP2) and MAPKAPK5. The intricacies of the complex formed with MAPKAPK5 are still under scrutiny, but a series of phosphorylation events unfolds within this interaction. Upon binding with atypical MAPKAPK5, ERK3/MAPK6 undergoes phosphorylation at Ser-189, subsequently facilitating the phosphorylation and activation of MAPKAPK5. In turn, activated MAPKAPK5 reciprocally phosphorylates ERK3/MAPK6. The precise functional implications of this complex interplay remain elusive, although it may play a role in promoting entry into the cell cycle.

Human

E. coli

N-6*His

Q16659 (M9-I327, L290V)

5597

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.