Erythropoietin/EPO Protein, Mouse (HEK293, solution)

This gene encodes the erythropoietin (EPO) protein that is critical for regulating erythropoiesis. It is mainly expressed in the liver during fetal development and is transferred to the kidneys in adults. Erythropoietin/EPO Protein, Mouse (HEK293, solution) is the recombinant mouse-derived Erythropoietin/EPO protein, expressed by HEK293 , with tag free. The total length of Erythropoietin/EPO Protein, Mouse (HEK293, solution) is 166 a.a., with molecular weight of ~18.6 kDa.

This gene encodes the glycoprotein hormone erythropoietin, which plays a crucial role in regulating red blood cell production and hemoglobin biosynthesis. While this gene is predominantly expressed in the liver during fetal development, it shifts to the kidneys in adults. Complete absence of the encoded protein leads to embryonic lethal anemia in mice, and conditional inactivation in adult mice results in chronic, normocytic, and normochromic anemia. Transgenic mice expressing the human ortholog of this gene exhibit polycythemia. Various isoforms are generated through alternative splicing. Notably, the expression of this gene is low in the reference dataset.

Measured in a cell proliferation assay using TF-1 human erythroleukemic cells.The ED₅₀ for this effect is typically 2-10 ng/mL.

Mouse

HEK293

Tag Free

NP_031968.1 (A27-R192)

13856  [NCBI]

MGVPERPTLLLLLSLLLIPLGLPVLCAPPRLICDSRVLERYILEAKEAENVTMGCAEGPRLSENITVPDTKVNFYAWKRMEVEEQAIEVWQGLSLLSEAILQAQALLANSSQPPETLQLHIDKAISGLRSLTSLLRVLGAQKELMSPPDTTPPAPLRTLTVDTFCKLFRVYANFLRGKLKLYTGEVCRRGDR

Approximately 23-36 kDa due to glycosylation.

Greater than 95% as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.