FACA/FANCA Protein, Human (sf9, His)

FANCA/FANCC proteins repair DNA and maintain chromosomal stability. FACA/FANCA Protein, Human (sf9, His) is the recombinant human-derived FACA/FANCA protein, expressed by Sf9 insect cells , with N-His labeled tag.

FANCA protein, an integral member of the Fanconi anemia (FA) complex, functions as a DNA repair protein with potential involvement in postreplication repair or cell cycle checkpoint activities. It plays a critical role in interstrand DNA cross-link repair and contributes to the maintenance of normal chromosome stability. As part of the multisubunit FA complex, which includes FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9, and FANCM, it is notably absent in individuals with Fanconi anemia. In collaboration with FANCF, FANCG, and FANCL, FANCA interacts with HES1, a crucial interaction for the stability and nuclear localization of FA core complex proteins. The complex formed by FANCA, FANCC, and FANCG may also incorporate EIF2AK2 and HSP70. Furthermore, FANCA directly interacts with FAAP20/C1orf86. These intricate interactions highlight FANCA's role in orchestrating the functions of the FA complex and emphasize its significance in DNA repair and genome stability maintenance.

Human

Sf9 insect cells

N-His

AAH08979.1 (M1-C297)

2175  [NCBI]

Approximately 35 kDa

Greater than 85% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.