FGL1 Protein, Rat (sf9, His)

The FGL1 protein is a key immunosuppressant that acts as the primary ligand of LAG3 to inhibit antigen-specific T cell activation. FGL1 is essential for the T cell suppressor function of LAG3, which is independent of MHC class II (MHC-II) binding. FGL1 is secreted by hepatocytes and actively promotes their growth. FGL1 Protein, Rat (sf9, His) is the recombinant rat-derived FGL1 protein, expressed by Sf9 insect cells , with C-His labeled tag.

FGL1 protein emerges as a pivotal immune suppressive molecule, orchestrating the inhibition of antigen-specific T-cell activation by serving as a primary ligand for LAG3. Its role is crucial in facilitating the T-cell inhibitory function of LAG3 independently of MHC class II (MHC-II) binding. Beyond its immune-modulating functions, FGL1 is secreted by hepatocytes, actively contributing to their growth. Existing in a homodimeric form, FGL1 establishes interactions with LAG3 through its Fibrinogen C-terminal domain, specifically binding to LAG3's Ig-like domains 1 and 2. This intricate molecular interplay positions FGL1 at the nexus of immune regulation and hepatocyte growth, underscoring its significance in the orchestration of T-cell activation and hepatic functions.

Rat

Sf9 insect cells

C-His

Q5M8C6 (L23-V314)

246186  [NCBI]

Approximately 35.48 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.