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  3. Galectin-8/LGALS8 Protein, Rat (GST)

Galectin-8 belongs to the family of animal lectins that bind to different glycoconjugates. Galectin-8 inhibits MTOR and AMPK signaling pathways to induce autophagy in response to lysosomal damage. Galectin-8 is highly expressed in a variety of tumors. Galectin-8/LGALS8 Protein, Rat (GST) is the recombinant rat-derived Galectin-8 protein, expressed by E. coli , with N-GST labeled tag.

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Description

Galectin-8 belongs to the family of animal lectins that bind to different glycoconjugates. Galectin-8 inhibits MTOR and AMPK signaling pathways to induce autophagy in response to lysosomal damage. Galectin-8 is highly expressed in a variety of tumors. Galectin-8/LGALS8 Protein, Rat (GST) is the recombinant rat-derived Galectin-8 protein, expressed by E. coli , with N-GST labeled tag.

Background

Galectin-8 belongs to the family of animal lectins that bind to different glycoconjugates. As a secreted protein, Galectin-8 is found in body fluids or the serum of patients with breast cancer and those with colon cancer. Extracellular Galectin-8 promotes cell adhesion by binding to cell adhesion molecules such as integrins CD44, CD166 and Podoplanin. Galectin-8 performs its intracellular function by marking the vacuoles invaded by pathogens to be destroyed by autophagy. Galectin-8 inhibited MTOR and AMPK in response to lysosomal injury induced autophagy in membrane disturbances. Galectin-8 is highly expressed in a variety of tumors[1][2][3].

Species

Rat

Source

E. coli

Tag

N-GST

Accession

Q6IN24 (M1-W316)

Gene ID
Molecular Construction
N-term
GST
Galectin-8/LGALS8 (M1-W316)
Accession # Q6IN24
C-term
Synonyms
Galectin-8; Gal-8; Po66 Carbohydrate-Binding Protein; Po66-CBP; Prostate Carcinoma Tumor Antigen 1; PCTA-1; LGALS8
Molecular Weight

Approximately 63.2 kDa

Purity

Greater than 90% as determined by reducing SDS-PAGE

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

Galectin-8/LGALS8 Protein, Rat (GST) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
Galectin-8/LGALS8 Protein, Rat (GST)
Cat. No.:
HY-P76943
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