glycoprotein/G Protein, HRSV (HEK293, His)

Glycoproteins/G proteins play a key role in infection by attaching viral particles to the host cell membrane through heparan sulfate interactions, thereby initiating infection. It also interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, contributing to immune regulation and promoting infection. glycoprotein/G Protein, HRSV (HEK293, His) is the recombinant Virus-derived glycoprotein/G protein, expressed by HEK293 , with C-His labeled tag.

The glycoprotein/G protein plays a pivotal role in infection by attaching the virion to the host cell membrane through interaction with heparan sulfate, initiating the infection. Additionally, it interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, contributing to immune modulation and facilitating infection. Distinguished from other paramyxovirus attachment proteins, the glycoprotein lacks both neuraminidase and hemagglutinating activities. Its unique features enable the virus to evade antibody-dependent restriction of replication by functioning as an antigen decoy and modulating the activity of leukocytes carrying Fc-gamma receptors.

Virus

HEK293

C-His

O36633-1 (H67-A299)

1489824  [NCBI]

80-90 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.