HA/Hemagglutinin Protein, H11N9 (ABB87228, HEK293, His)

The hemagglutinin (HA) protein is essential for viral attachment to host cells, binding to sialic acid receptors, and initiating virion internalization through clathrin-dependent or -independent pathways. As a class I viral fusion protein, HA determines host range and virulence, mediating viral penetration into the cytoplasm. Hemagglutinin/HA Protein, H11N9 (ABB87228, HEK293, His) is the recombinant Virus-derived Hemagglutinin/HA protein, expressed by HEK293 , with C-His labeled tag.

The Hemagglutinin (HA) protein is central to the attachment of virus particles to host cells by binding to sialic acid-containing receptors on the cell surface. This interaction leads to virion internalization through either clathrin-dependent endocytosis or a clathrin- and caveolin-independent pathway. HA plays a pivotal role in determining host range restriction and virulence, functioning as a Class I viral fusion protein responsible for the penetration of the virus into the cell cytoplasm. Its mediation of the fusion between the membrane of the endocytosed virus particle and the endosomal membrane is essential for successful infection. The acidic environment in endosomes induces an irreversible conformational change in the HA2 subunit, releasing the fusion hydrophobic peptide. The formation of a competent fusion pore requires the cooperative action of several HA trimers, highlighting the intricate molecular processes orchestrated by HA during viral entry.

Virus

HEK293

C-His

ABB87228 (D17-K528)

/

65-70 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.