HA/Hemagglutinin Protein, H3N2 (P03437, sf9, His)

HA/Hemagglutinin Protein binds to cell surface receptors, facilitating virus attachment.It determines host range and virulence.As a class I fusion protein, it mediates fusion of virus and endosomal membranes for cell penetration.Acidic endosomes trigger HA2 conformational change, releasing fusion peptide.Multiple HA trimers are needed for fusion pore formation.HA/Hemagglutinin Protein, H3N2 (P03437, sf9, His) is the recombinant Virus-derived HA/Hemagglutinin protein, expressed by Sf9 insect cells , with C-His labeled tag.

HA/Hemagglutinin Protein binds to sialic acid-containing receptors on the cell surface, facilitating the attachment of the virus particle to the cell. This attachment leads to the internalization of approximately two thirds of the virus particles through clathrin-dependent endocytosis and around one third through a clathrin- and caveolin-independent pathway. It plays a crucial role in determining the host range restriction and virulence. As a class I viral fusion protein, it is responsible for mediating the fusion of the endocytosed virus particle membrane with the endosomal membrane, enabling the penetration of the virus into the cell cytoplasm. The acidic environment in endosomes triggers an irreversible conformational change in HA2, resulting in the release of the fusion hydrophobic peptide. Multiple trimers of HA/Hemagglutinin Protein are necessary to form a functional fusion pore.

Virus

Sf9 insect cells

C-His

P03437 (Q17-W530)

/

Approximately 59 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.