HA/Hemagglutinin Protein, H5N1 (Q9Q0U6, sf9, His)

The HA/hemagglutinin protein binds to cell surface receptors, allowing viral particles to attach. This initiates viral particle internalization through different pathways. HA/Hemagglutinin Protein, H5N1 (Q9Q0U6, sf9, His) is the recombinant Virus-derived HA/Hemagglutinin protein, expressed by Sf9 insect cells , with C-His labeled tag.

The Hemagglutinin Protein (HA) binds to receptors on the cell surface, facilitating the attachment of the virus particle to the cell. This attachment leads to internalization of the virion through different pathways. HA also plays a crucial role in determining the host range restriction and virulence of the virus. As a class I viral fusion protein, HA is responsible for mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane, allowing the virus to enter the cell cytoplasm. In the low pH environment of endosomes, HA2 undergoes a conformational change, releasing the fusion hydrophobic peptide. Multiple HA trimers are needed to form a competent fusion pore. HA is a homotrimer consisting of disulfide-linked HA1-HA2 subunits.

Virus

Sf9 insect cells

C-His

Q9Q0U6/YP_308669.1 (D17-E340)

3654620  [NCBI]

Approximately 60.1 kDa

Greater than 85% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.