ICAM-2/CD102 Protein, Mouse (HEK293, Fc)

The ICAM-2/CD102 protein is a key player in cellular interactions, acting as a ligand for the leukocyte adhesion protein LFA-1. It inhibits LFA-1-dependent cell adhesion and contributes to lymphocyte recycling. ICAM-2/CD102 Protein, Human (HEK293, His, solution) is the recombinant mouse-derived ICAM-2/CD102 protein, expressed by HEK293 , with C-hFc labeled tag.

ICAM-2/CD102 protein emerges as a significant participant in cellular interactions, functioning as a ligand for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). Notably, ICAM-2 may contribute to lymphocyte recirculation by inhibiting LFA-1-dependent cell adhesion. Its involvement extends to mediating adhesive interactions crucial for various immune processes, including antigen-specific immune responses, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions vital for immune response and surveillance. The protein further interacts with RDX, EZR, and MSN, emphasizing its intricate associations in the cellular machinery that underlies immune regulation and surveillance.

Mouse

HEK293

C-hFc

P35330 (K23-Q222)

15896  [NCBI]

KAFEVYIWSEKQIVEATESWKINCSTNCAAPDMGGLETPTNKIMLEEHPQGKWKQFLVSNVSKDTVFFCHFTCSGKQHSESLNIRVYQPPAQVTLKLQPPRVFVGEDFTIECTVSPVQPLERLTLSLLRGRETLKNQTFGGAETVPQEATATFNSTALKKDGLNFSCQAELDLRPHGGYIIRSISEYQILEVYEPMQDNQ

70-90 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.